Koichi M Iijima
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Explore the profile of Koichi M Iijima including associated specialties, affiliations and a list of published articles.
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27
Citations
519
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Recent Articles
1.
Chikamatsu S, Sakakibara Y, Takei K, Nishijima R, Iijima K, Sekiya M
J Biochem
. 2024 Dec;
177(3):225-237.
PMID: 39696747
Sleep quality and quantity decrease with age, and sleep disturbance increases the risk of many age-associated diseases. There is a significant relationship between nutritional status and sleep outcomes, with malnutrition...
2.
Sekiya M, Sakakibara Y, Hirota Y, Ito N, Chikamatsu S, Takei K, et al.
Neurobiol Dis
. 2024 Oct;
202:106694.
PMID: 39374707
Alzheimer's disease (AD) is a progressive neurodegenerative disease and a leading cause of senile dementia. Amyloid-β (Aβ) accumulation triggers chronic neuroinflammation, initiating AD pathogenesis. Recent clinical trials for anti-Aβ immunotherapy...
3.
Shinno K, Miura Y, Iijima K, Suzuki E, Ando K
bioRxiv
. 2024 Jan;
PMID: 38293064
Neuronal aging and neurodegenerative diseases are accompanied by proteostasis collapse, while cellular factors that trigger it are not identified. Impaired mitochondrial transport in the axon is another feature of aging...
4.
Maruko A, Iijima K, Ando K
iScience
. 2023 Nov;
26(11):108164.
PMID: 37915609
A 24-h rhythm of feeding behavior, or synchronized feeding/fasting episodes during the day, is crucial for survival. Internal clocks and light input regulate rhythmic behaviors, but how they generate feeding...
5.
Hirota Y, Sakakibara Y, Takei K, Nishijima R, Sekiya M, Iijima K
J Alzheimers Dis
. 2023 May;
93(3):1065-1081.
PMID: 37212118
Background: The tau protein phosphorylated at Thr181 (p-tau181) in cerebrospinal fluid and blood is a sensitive biomarker for Alzheimer's disease (AD). Increased p-tau181 levels correlate well with amyloid-β (Aβ) pathology...
6.
Sakakibara Y, Yamashiro R, Chikamatsu S, Hirota Y, Tsubokawa Y, Nishijima R, et al.
iScience
. 2023 Jan;
26(2):105968.
PMID: 36718365
Toll-9 is most closely related to mammalian Toll-like receptors; however, physiological functions of Toll-9 remain elusive. We examined the roles of Toll-9 in fly brains in aging and neurodegeneration. mRNA...
7.
Hirota Y, Sakakibara Y, Ibaraki K, Takei K, Iijima K, Sekiya M
Brain Commun
. 2022 Nov;
4(6):fcac286.
PMID: 36440096
Phospho-tau 217, phospho-tau 231 and phospho-tau 181 in cerebrospinal fluid and plasma are promising biomarkers for the diagnosis of Alzheimer's disease. All these p-tau proteins are detected in neurofibrillary tangles...
8.
Nozawa N, Noguchi M, Shinno K, Tajima M, Aizawa S, Saito T, et al.
FEBS Open Bio
. 2021 Dec;
12(1):295-305.
PMID: 34854258
Declines in mitochondrial functions are associated with aging. The combination of 5-aminolevulinic acid (5-ALA) and sodium ferrous citrate (SFC) improves mitochondrial functions in cultured cells. In this study, we investigated...
9.
Sakakibara Y, Hirota Y, Ibaraki K, Takei K, Chikamatsu S, Tsubokawa Y, et al.
J Alzheimers Dis
. 2021 Jun;
82(4):1513-1530.
PMID: 34180416
Background: The locus coeruleus (LC), a brainstem nucleus comprising noradrenergic neurons, is one of the earliest regions affected by Alzheimer's disease (AD). Amyloid-β (Aβ) pathology in the cortex in AD...
10.
Sekiya M, Iijima K
STAR Protoc
. 2021 May;
2(2):100501.
PMID: 33997815
For decades, the fruit fly has been an efficient genetic model to investigate many aspects of human neurodegenerative diseases. Through genetic and pharmacologic approaches, these studies have revealed the molecular...