Kiyotaka Y Hara
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Explore the profile of Kiyotaka Y Hara including associated specialties, affiliations and a list of published articles.
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53
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1152
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Recent Articles
1.
Chen Y, Cui M, Liu B, Gao L, Mitome N, Hirono-Hara Y, et al.
ACS Appl Mater Interfaces
. 2024 Jul;
16(29):37521-37529.
PMID: 38985575
Sodium ions and protons regulate various fundamental processes at the cell and tissue levels across all biological kingdoms. It is therefore pivotal for bioelectronic devices, such as biosensors and biotransducers,...
2.
Chen Y, Mehes G, Liu B, Gao L, Cui M, Lin C, et al.
ACS Appl Mater Interfaces
. 2024 Jan;
16(6):7480-7488.
PMID: 38295806
Ion channels are membrane proteins that allow ionic signals to pass through channel pores for biofunctional modulations. However, biodevices that integrate bidirectional biological signal transmission between a device and biological...
3.
Matsuyama C, Seike T, Okahashi N, Niide T, Hara K, Hirono-Hara Y, et al.
J Biosci Bioeng
. 2024 Jan;
137(3):187-194.
PMID: 38281859
Overexpression of proteins by introducing a DNA vector is among the most important tools for the metabolic engineering of microorganisms such as Escherichia coli. Protein overexpression imposes a burden on...
4.
Daicho K, Hirono-Hara Y, Kikukawa H, Tamura K, Hara K
Microb Cell Fact
. 2024 Jan;
23(1):4.
PMID: 38172917
Background: The supply of ATP is a limiting factor for cellular metabolism. Therefore, cell factories require a sufficient ATP supply to drive metabolism for efficient bioproduction. In the current study,...
5.
Kikukawa H, Nagao T, Ota M, Takashima S, Kitaguchi K, Yanase E, et al.
Microbiome Res Rep
. 2023 Dec;
2(1):4.
PMID: 38045611
C16 monounsaturated fatty acid (C16:1) show antibacterial activity against , a pathogen associated with various diseases such as atopic dermatitis and bacteremia, while the compound does not exhibit antibacterial activity...
6.
Kikukawa H, Ando A, Hannya A, Asras M, Okuda T, Sakamoto T, et al.
J Biosci Bioeng
. 2023 Aug;
136(5):353-357.
PMID: 37635046
Mead acid (MA; 20:3ω9) is one of the ω9 series of polyunsaturated fatty acids (PUFAs). MA is used to inhibit the inflammation of joints and is applied to the medicinal...
7.
Sano M, Tanaka R, Kamata K, Hirono-Hara Y, Ishii J, Matsuda F, et al.
ACS Synth Biol
. 2022 Nov;
11(12):3966-3972.
PMID: 36441576
Bioconversion of key intermediate metabolites such as mevalonate into various useful chemicals is a promising strategy for microbial production. However, the conversion of mevalonate into isoprenoids requires a supply of...
8.
Otsuka K, Seike T, Toya Y, Ishii J, Hirono-Hara Y, Hara K, et al.
J Biosci Bioeng
. 2022 Sep;
134(6):484-490.
PMID: 36171161
A light-driven ATP regeneration system using rhodopsin has been utilized as a method to improve the production of useful substances by microorganisms. To enable the industrial use of this system,...
9.
Kobayashi J, Sasaki D, Hara K, Hasunuma T, Kondo A
Microb Cell Fact
. 2022 Aug;
21(1):153.
PMID: 35933377
Background: Glutathione is a valuable tri-peptide that is industrially produced by fermentation using the yeast Saccharomyces cerevisiae, and is widely used in the pharmaceutical, food, and cosmetic industries. It has...
10.
Toya Y, Hirono-Hara Y, Hirayama H, Kamata K, Tanaka R, Sano M, et al.
Metab Eng
. 2022 Mar;
72:227-236.
PMID: 35346842
In microbial fermentative production, ATP regeneration, while crucial for cellular processes, conflicts with efficient target chemical production because ATP regeneration exhausts essential carbon sources also required for target chemical biosynthesis....