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Kiyotaka Nishikawa

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Articles 46
Citations 563
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Recent Articles
1.
Hama S, Watanabe-Takahashi M, Nishimura H, Omi J, Tamada M, Saitoh T, et al.
mBio . 2024 Nov; 16(1):e0008724. PMID: 39601535
Ca/calmodulin-dependent protein kinase II (CaMKII) is one of hundreds of host-cell factors involved in the propagation of type A influenza virus (IAV), although its mechanism of action is unknown. Here,...
2.
Watanabe-Takahashi M, Tanigawa T, Hamabata T, Nishikawa K
Biochem Biophys Res Commun . 2024 Oct; 734:150769. PMID: 39369542
Infection by enterotoxigenic Escherichia coli (ETEC) causes severe watery diarrhea and dehydration in humans. Heat-labile enterotoxin (LT) is a major virulence factor produced by ETEC. LT is one of AB-type...
3.
Watanabe-Takahashi M, Kumoi K, Yamamoto H, Shimizu E, Motoyama J, Hamabata T, et al.
Biochem Biophys Res Commun . 2024 May; 716:149991. PMID: 38704888
Cholera toxin (Ctx) is a major virulence factor produced by Vibrio cholerae that can cause gastrointestinal diseases, including severe watery diarrhea and dehydration, in humans. Ctx binds to target cells...
4.
Sato W, Watanabe-Takahashi M, Murata T, Utsunomiya-Tate N, Motoyama J, Anzai M, et al.
Commun Biol . 2023 Apr; 6(1):383. PMID: 37031306
Inhibition of amyloid-β peptide (Aβ) accumulation in the brain is a promising approach for treatment of Alzheimer's disease (AD). Aβ is produced by β-secretase and γ-secretase in endosomes via sequential...
5.
Deguchi A, Watanabe-Takahashi M, Mishima T, Omori T, Ohto U, Arashiki N, et al.
Cancer Gene Ther . 2023 Mar; 30(7):973-984. PMID: 36932197
The tumor-elicited inflammation is closely related to tumor microenvironment during tumor progression. S100A8, an endogenous ligand of Toll-like receptor 4 (TLR4), is known as a key molecule in the tumor...
6.
Anzai M, Watanabe-Takahashi M, Kawabata H, Mizuno S, Taguchi Y, Inoue J, et al.
Biochem Biophys Res Commun . 2022 Nov; 636(Pt 1):178-183. PMID: 36334442
Inhibition of osteoclast differentiation is a promising approach for the treatment of osteoporosis and rheumatoid arthritis. Receptor activator of nuclear factor kappa B (NF-κB) (RANK), which is an essential molecule...
7.
Li Y, Kuroki K, Shimakami T, Murai K, Kawaguchi K, Shirasaki T, et al.
Cell Mol Gastroenterol Hepatol . 2022 Oct; 15(3):533-558. PMID: 36270602
Background & Aims: Hepatitis B virus (HBV) infection is difficult to cure owing to the persistence of covalently closed circular viral DNA (cccDNA). We performed single-cell transcriptome analysis of newly...
8.
Hama S, Nakahara M, Watanabe-Takahashi M, Shimizu E, Tsutsuki H, Yahiro K, et al.
Biochem Biophys Res Commun . 2022 Sep; 629:95-100. PMID: 36115284
Subtilase cytotoxin (SubAB) is a major virulence factor produced by eae-negative Shiga-toxigenic Escherichia coli (STEC) that can cause fatal systemic complications. SubAB binds to target cells through multivalent interactions between...
9.
Watanabe-Takahashi M, Senda M, Yoshino R, Hibino M, Hama S, Terada T, et al.
Sci Rep . 2022 Jul; 12(1):11443. PMID: 35794188
Shiga toxin (Stx), a major virulence factor of enterohemorrhagic Escherichia coli (EHEC), can cause fatal systemic complications. Recently, we identified a potent inhibitory peptide that binds to the catalytic A-subunit...
10.
Watanabe-Takahashi M, Tamada M, Senda M, Hibino M, Shimizu E, Okuta A, et al.
Commun Biol . 2021 May; 4(1):538. PMID: 33972673
Shiga toxin (Stx) is a major virulence factor of enterohemorrhagic Escherichia coli, which causes fatal systemic complications. Here, we identified a tetravalent peptide that inhibited Stx by targeting its receptor-binding,...