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Kirtika Madan

Explore the profile of Kirtika Madan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 17
Followers 0
Related Specialties
Pharmacology
Chemistry
Allergy & Immunology
Top 10 Co-Authors
Swapnil Sharma
Sarvesh Paliwal
Seema Kesar
Neha Chauhan
Monika Chauhan
Pooja Mishra
Mansi Madan
Richa Arya
Kanika Verma
Sarvesh K Paliwal
Published In
Cent Nerv Syst Agents Med Chem
ACS Med Chem Lett
Curr Drug Discov Technol
Curr Comput Aided Drug Des
Comb Chem High Throughput Screen
Affiliations
Soon will be listed here.
Recent Articles
1.
QSAR Studies and Scaffold Optimization of Predicted Novel ACC 2 Inhibitors to Treat Metabolic Syndrome
Madan K, Paliwal S, Sharma S, Kesar S, Chauhan N, Madan M
Curr Drug Discov Technol . 2023 Sep; 21(2):e010923220643. PMID: 37680153
Background: Metabolic syndrome is one of the major non-communicable global health hazards of the modern world owing to its amplifying prevalence. Acetyl coenzyme-A carboxylase 2 (ACC 2) is one of...
2.
Metabolic Syndrome: The Constellation of Co-morbidities, A Global Threat
Madan K, Paliwal S, Sharma S, Kesar S, Chauhan N, Madan M
Endocr Metab Immune Disord Drug Targets . 2023 Mar; 23(12):1491-1504. PMID: 36892127
Background: Metabolic syndrome, also referred to as Syndrome X or obesity syndrome is a cluster of diseases prevalent worldwide in both developed and developing countries. According to WHO, it is...
3.
In-silico Studies and Biological Activity of Potential BACE-1 Inhibitors
Arya R, Paliwal S, Gupta S, Sharma S, Madan K, Mishra A, et al.
Comb Chem High Throughput Screen . 2020 Sep; 24(5):729-736. PMID: 32957879
Background: Alzheimer's disease is a neurological condition causing cognitive inability and dementia. The pathological lesions and neuronal damage in the brain are caused by self-aggregated fragments of mutated Amyloidal precursor...
4.
Identification of Novel Rho-Kinase-II Inhibitors with Vasodilatory Activity
Kesar S, Paliwal S, Mishra P, Madan K, Chauhan M, Chauhan N, et al.
ACS Med Chem Lett . 2020 Sep; 11(9):1694-1703. PMID: 32944136
Small GTPase protein Rho-kinase (ROCK) plays an important role in the pathogenesis of hypertension. Inhibition of ROCK II brings about the biochemical changes leading to vascular smooth muscles relaxation, finally...
5.
Chitinases: Therapeutic Scaffolds for Allergy and Inflammation
Madan K, Madan M, Sharma S, Paliwal S
Recent Pat Inflamm Allergy Drug Discov . 2020 Jan; 14(1):46-57. PMID: 31934842
Background: Chitinases are the evolutionary conserved glycosidic enzymes that are characterized by their ability to cleave the naturally abundant polysaccharide chitin. The potential role of chitinases has been identified in...
6.
In-Silico QSAR Modelling of Predicted Rho Kinase Inhibitors Against Cardio Vascular Diseases
Kesar S, Paliwal S, Sharma S, Mishra P, Chauhan M, Arya R, et al.
Curr Comput Aided Drug Des . 2019 Mar; 15(5):421-432. PMID: 30848208
Background: Rho-kinase is an essential downstream target of GTP-binding protein RhoA, and plays a crucial role in the calcium-sensitization pathway. Rho-kinase pathway is critically involved in phosphorylation state of myosin...
7.
In-Silico Screening of Ligand Based Pharmacophore, Database Mining and Molecular Docking on 2, 5-Diaminopyrimidines Azapurines as Potential Inhibitors of Glycogen Synthase Kinase-3β
Mishra P, Kesar S, Paliwal S, Chauhan M, Madan K
Cent Nerv Syst Agents Med Chem . 2018 Jun; 18(2):150-158. PMID: 29848281
Background: Glycogen synthase kinase-3β plays a significant role in the regulation of various pathological pathways relating to the Central Nervous System (CNS). Dysregulation of Glycogen synthase kinase 3 (GSK-3) activity...