Kirill Sechkar
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Explore the profile of Kirill Sechkar including associated specialties, affiliations and a list of published articles.
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3
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8
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Recent Articles
1.
Sechkar K, Steel H
J R Soc Interface
. 2025 Feb;
22(223):20240602.
PMID: 39933591
Maintaining engineered cell populations' genetic stability is a key challenge in synthetic biology. Synthetic genetic constructs compete with a host cell's native genes for expression resources, burdening the cell and...
2.
Gallup O, Sechkar K, Towers S, Steel H
ACS Synth Biol
. 2024 Sep;
13(9):3046-3050.
PMID: 39230510
Mathematical modeling is indispensable in synthetic biology but remains underutilized. Tackling problems, from optimizing gene networks to simulating intracellular dynamics, can be facilitated by the ever-growing body of modeling approaches,...
3.
Sechkar K, Steel H, Perrino G, Stan G
Nat Commun
. 2024 Mar;
15(1):1981.
PMID: 38438391
Within a cell, synthetic and native genes compete for expression machinery, influencing cellular process dynamics through resource couplings. Models that simplify competitive resource binding kinetics can guide the design of...
4.
Sechkar K, Tuza Z, Stan G
Synth Biol (Oxf)
. 2022 May;
7(1):ysac004.
PMID: 35540864
Laboratory automation and mathematical optimization are key to improving the efficiency of synthetic biology research. While there are algorithms optimizing the construct designs and synthesis strategies for DNA assembly, the...