Kingshuk Ghosh
Overview
Explore the profile of Kingshuk Ghosh including associated specialties, affiliations and a list of published articles.
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51
Citations
916
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Recent Articles
1.
Huang Z, Ghosh K, Stull F, Horowitz S
Proc Natl Acad Sci U S A
. 2025 Feb;
122(6):e2414045122.
PMID: 39913211
Many proteins have slow folding times in vitro that are physiologically untenable. To combat this challenge, ATP-dependent chaperonins are thought to possess the unique ability to catalyze protein folding. Performing...
2.
Houston L, Phillips M, Torres A, Gaalswyk K, Ghosh K
J Chem Theory Comput
. 2024 Nov;
20(22):10266-10274.
PMID: 39504303
Intrinsically disordered proteins and regions (IDPs) are involved in vital biological processes. To understand the IDP function, often controlled by conformation, we need to find the link between sequence and...
3.
Phillips M, Muthukumar M, Ghosh K
PNAS Nexus
. 2024 Sep;
3(9):pgae367.
PMID: 39253398
Conformations and dynamics of an intrinsically disordered protein (IDP) depend on its composition of charged and uncharged amino acids, and their specific placement in the protein sequence. In general, the...
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5.
Firouzbakht A, Haider A, Gaalswyk K, Alaeen S, Ghosh K, Gruebele M
Proc Natl Acad Sci U S A
. 2024 Apr;
121(18):e2316408121.
PMID: 38657047
Intrinsically disordered proteins (IDPs) that lie close to the empirical boundary separating IDPs and folded proteins in Uversky's charge-hydropathy plot may behave as "marginal IDPs" and sensitively switch conformation upon...
6.
Valverde J, Dubra G, Phillips M, Haider A, Elena-Real C, Fournet A, et al.
Nat Commun
. 2023 Oct;
14(1):6316.
PMID: 37813838
Cell cycle transitions result from global changes in protein phosphorylation states triggered by cyclin-dependent kinases (CDKs). To understand how this complexity produces an ordered and rapid cellular reorganisation, we generated...
7.
Torres A, Cockerell S, Phillips M, Balazsi G, Ghosh K
Biophys J
. 2023 May;
122(13):2623-2635.
PMID: 37218129
Gene expression is inherently noisy due to small numbers of proteins and nucleic acids inside a cell. Likewise, cell division is stochastic, particularly when tracking at the level of a...
8.
Gaalswyk K, Haider A, Ghosh K
J Chem Theory Comput
. 2023 May;
19(10):2973-2984.
PMID: 37133846
All atom simulations can be used to quantify conformational properties of Intrinsically Disordered Proteins (IDP). However, simulations must satisfy convergence checks to ensure observables computed from simulation are reliable and...
9.
Ghosh K, Huihui J, Phillips M, Haider A
Annu Rev Biophys
. 2022 Feb;
51:355-376.
PMID: 35119946
In stark contrast to foldable proteins with a unique folded state, intrinsically disordered proteins and regions (IDPs) persist in perpetually disordered ensembles. Yet an IDP ensemble has conformational features-even when...
10.