Kimberly K Jefferson
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Explore the profile of Kimberly K Jefferson including associated specialties, affiliations and a list of published articles.
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60
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3576
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Recent Articles
1.
Garcia E, Klimowicz A, Edupuganti L, Topf M, Bhide S, Slusser D, et al.
mSphere
. 2024 Jun;
9(7):e0045024.
PMID: 38926904
The genus, comprising at least 13 species, is associated with the polymicrobial disorder bacterial vaginosis (BV). However, the details of BV pathogenesis are poorly defined, and the contributions made by...
2.
McCoy Z, Serrano M, Edupuganti L, Spaine K, Edwards D, Buck G, et al.
Immunohorizons
. 2024 Jan;
8(1):114-121.
PMID: 38276916
Sneathia vaginalis is a Gram-negative vaginal species that is associated with pregnancy complications. It produces cytopathogenic toxin A (CptA), a pore-forming toxin. To determine whether CptA is expressed in vivo...
3.
OBrien C, Raskin J, Amankwa Asare I, Wei C, Ma J, McCoy Z, et al.
PLoS One
. 2023 May;
18(5):e0284349.
PMID: 37141247
The association between Sneathia vaginalis and preterm birth is emerging. The Gram-negative anaerobe produces a large exotoxin, the cytopathogenic toxin A (CptA), that forms pores in human epithelial cells and...
4.
Glascock A, Jimenez N, Boundy S, Koparde V, Brooks J, Edwards D, et al.
Microb Genom
. 2021 Dec;
7(12).
PMID: 34898422
The composition of the human vaginal microbiome has been extensively studied and is known to influence reproductive health. However, the functional roles of individual taxa and their contributions to negative...
5.
Allen N, Edupuganti L, Edwards D, Jimenez N, Buck G, Jefferson K, et al.
Obesity (Silver Spring)
. 2021 Nov;
30(1):142-152.
PMID: 34806323
Objective: The aim of this study was to evaluate the differences between the vaginal microbiome of reproductive-aged women with overweight and obesity (Ow/Ob) compared with healthy weight (HW). Methods: In...
6.
Kumar N, Contaifer Jr D, Wijesinghe D, Jefferson K
PLoS One
. 2021 Oct;
16(10):e0258106.
PMID: 34618844
Bacterial lipases play important roles during infection. The Staphylococcus aureus genome contains several genes that encode well-characterized lipases and several genes predicted to encode lipases or esterases for which the...
7.
Wright M, Fettweis J, Eaves L, Silberg J, Neale M, Serrano M, et al.
Commun Biol
. 2021 Aug;
4(1):872.
PMID: 34354222
The diversity and dominant bacterial taxa in the vagina are reported to be influenced by multiple intrinsic and extrinsic factors, including but not limited to pregnancy, contraceptive use, pathogenic states,...
8.
Garcia E, Serrano M, Edupuganti L, Edwards D, Buck G, Jefferson K
Pathogens
. 2021 Jan;
10(2).
PMID: 33498226
has recently been split into 13 distinct species. In this study, we tested the hypotheses that species-specific variations in the vaginolysin (VLY) amino acid sequence could influence the interaction between...
9.
Gentile G, Rupert A, Carrasco L, Garcia E, Kumar N, Walsh S, et al.
J Bacteriol
. 2020 Apr;
202(13).
PMID: 32291280
is a poorly characterized emerging pathogen that has been implicated in amnionitis and urethritis. We found that damages fetal membranes, and we identified and purified a cytotoxic exotoxin that lyses...
10.
Walsh S, Nugent W, Alam S, Washington S, Teves M, Jefferson K, et al.
Reprod Sci
. 2020 Feb;
27(1):246-259.
PMID: 32046375
Decidual macrophages secrete proteases that activate protease-activated receptor 1 (PAR-1). We hypothesized that activation of the inflammatory response by bacteria is amplified by proteases, initiating labor. In addition, we hypothesized...