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Kim M Brown

Explore the profile of Kim M Brown including associated specialties, affiliations and a list of published articles. Areas
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Articles 6
Citations 270
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Brown K, Day J, Huston E, Zimmermann B, Hampel K, Christian F, et al.
Proc Natl Acad Sci U S A . 2013 Mar; 110(16):E1533-42. PMID: 23509299
V-raf-1 murine leukemia viral oncogene homolog 1 (Raf-1) is a key activator of the ERK pathway and is a target for cross-regulation of this pathway by the cAMP signaling system....
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Brown K, Lee L, Findlay J, Day J, Baillie G
FEBS Lett . 2012 Jun; 586(11):1631-7. PMID: 22673573
The cyclic AMP-specific phosphodiesterase PDE8 has been shown to play a pivotal role in important processes such as steroidogenesis, T cell adhesion, regulation of heart beat and chemotaxis. However, no...
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Bjorgo E, Solheim S, Abrahamsen H, Baillie G, Brown K, Berge T, et al.
Mol Cell Biol . 2010 Jan; 30(7):1660-72. PMID: 20086095
Engagement of the T-cell receptor (TCR) in human primary T cells activates a cyclic AMP (cAMP)-protein kinase A (PKA)-Csk inhibitory pathway that prevents full T-cell activation in the absence of...
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Vecsey C, Baillie G, Jaganath D, Havekes R, Daniels A, Wimmer M, et al.
Nature . 2009 Oct; 461(7267):1122-5. PMID: 19847264
Millions of people regularly obtain insufficient sleep. Given the effect of sleep deprivation on our lives, understanding the cellular and molecular pathways affected by sleep deprivation is clearly of social...
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Li X, MacLeod R, Dunlop A, Edwards H, Advant N, Gibson L, et al.
FEBS Lett . 2009 Sep; 583(20):3310-6. PMID: 19782076
Beta arrestins are molecular scaffolds that can bring together three-component mitogen-activated protein kinase signalling modules to promote signal compartmentalisation. We use peptide array technology to define novel interfaces between components...