Kim Kiat Lim
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Explore the profile of Kim Kiat Lim including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
94
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Recent Articles
1.
Lim K, Chen E
STAR Protoc
. 2024 May;
5(2):103076.
PMID: 38768030
Conventional colony-forming unit assay to measure cell viability is laborious and results in large experimental variability, which prohibits accurate quantification of microbial viability. Here, we present a microscopy-based protocol for...
2.
Lim K, Lam U, Li Y, Zeng Y, Yang H, Chen E
Nucleic Acids Res
. 2024 Mar;
52(8):4198-4214.
PMID: 38442274
Precise positioning of the histone-H3 variant, CENP-A, ensures centromere stability and faithful chromosomal segregation. Mislocalization of CENP-A to extra-centromeric loci results in aneuploidy and compromised cell viability associated with formation...
3.
Lim K, Koh N, Zeng Y, Chuan J, Raechell R, Chen E
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37445861
5-Fluorouracil (5-FU) is a conventional chemotherapeutic drug widely used in clinics worldwide, but development of resistance that compromises responsiveness remains a major hurdle to its efficacy. The mechanism underlying 5-FU...
4.
Lim K, Chen E
Bio Protoc
. 2021 Sep;
8(24):e3117.
PMID: 34532559
DNA damage repair proteins form foci in response to DNA damaging agents. The efficiency and integrity of the DNA repair pathway of a particular eukaryotic (mutant) strain is usually determined...
5.
Lim K, Teo H, Tan Y, Zeng Y, Lam U, Choolani M, et al.
Int J Mol Sci
. 2021 Jan;
22(2).
PMID: 33440639
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate metabolic pathway, and its loss of function through polymorphisms is often associated with human conditions, including cancer, congenital heart disease,...
6.
Seah K, Loh J, Nguyen T, Tan H, Hutchinson P, Lim K, et al.
Exp Cell Res
. 2018 Jul;
370(2):283-291.
PMID: 29959912
Chemotherapy remains the most prescribed anti-cancer therapy, despite patients suffering severe side effects and frequently developing chemoresistance. These complications can be partially overcome by combining different chemotherapeutic agents that target...
7.
Lim K, Nguyen T, Li A, Yeo Y, Chen E
Nucleic Acids Res
. 2018 Apr;
46(10):5061-5074.
PMID: 29635344
The Set2 methyltransferase and its target, histone H3 lysine 36 (H3K36), affect chromatin architecture during the transcription and repair of DNA double-stranded breaks. Set2 also confers resistance against the alkylating...
8.
Tan H, Lim K, Yang Q, Fan J, Sayed A, Low L, et al.
Nucleic Acids Res
. 2017 Dec;
46(3):1167-1179.
PMID: 29194511
Centromeric identity and chromosome segregation are determined by the precise centromeric targeting of CENP-A, the centromere-specific histone H3 variant. The significance of the amino-terminal domain (NTD) of CENP-A in this...
9.
Nguyen T, Lim Y, Fan M, Jackson R, Lim K, Ang W, et al.
Genes Cells
. 2016 Feb;
21(3):226-40.
PMID: 26891792
Doxorubicin is a widely used chemotherapeutic agent, but its utility is limited by cellular resistance and off-target effects. To understand the molecular mechanisms regulating chemotherapeutic responses to doxorubicin, we previously...
10.
Nguyen T, Chua J, Seah K, Koo S, Yee J, Yang E, et al.
Sci Rep
. 2016 Jan;
6:18658.
PMID: 26791325
Contemporary chemotherapeutic treatments incorporate the use of several agents in combination. However, selecting the most appropriate drugs for such therapy is not necessarily an easy or straightforward task. Here, we...