Kim Brosen
Overview
Explore the profile of Kim Brosen including associated specialties, affiliations and a list of published articles.
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Articles
123
Citations
1419
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Recent Articles
1.
Agergaard K, Thiesson H, Carstens J, Staatz C, Jarvinen E, Nielsen F, et al.
Br J Clin Pharmacol
. 2024 Oct;
91(3):761-773.
PMID: 39390741
Aim: Therapeutic drug monitoring of tacrolimus based on whole blood drug concentrations is routinely performed. The concentration of tacrolimus in peripheral blood mononuclear cells (PMBCs) is likely to better reflect...
2.
Iversen D, Dalgard Dunvald A, Ernst M, Abtahi S, Souverein P, Klungel O, et al.
Br J Clin Pharmacol
. 2024 Aug;
90(12):3252-3262.
PMID: 39160000
Aim: We aimed to assess if dicloxacillin/flucloxacillin reduces the therapeutic efficacy of direct oral anticoagulants (DOACs) and the underlying molecular mechanism. Methods: In a randomized, crossover study, we assessed whether...
3.
Iversen D, Dalgard Dunvald A, Jespersen D, Nielsen F, Brosen K, Damkier P, et al.
Clin Pharmacol Ther
. 2023 May;
114(2):434-445.
PMID: 37235733
Flucloxacillin is a widely used antibiotic. It is an agonist to the nuclear receptor PXR that regulates the expression of cytochrome P450 (CYP) enzymes. Treatment with flucloxacillin reduces warfarin efficacy...
4.
Frederiksen T, Areberg J, Schmidt E, Stage T, Brosen K
Clin Transl Sci
. 2023 Mar;
16(6):1012-1020.
PMID: 36869607
Polymorphism of the CYP2D6 gene leads to substantial interindividual variability in CYP2D6 enzyme activity. Despite improvements in prediction of CYP2D6 activity based on genotype information, large interindividual variability within CYP2D6...
5.
Frederiksen T, Areberg J, Raoufinia A, Schmidt E, Stage T, Brosen K
Clin Pharmacol Ther
. 2022 Nov;
113(2):360-369.
PMID: 36350097
Accurate prediction of CYP2D6 phenotype from genotype information is important to support safe and efficacious pharmacotherapy with CYP2D6 substrates. To facilitate accurate CYP2D6 genotype-phenotype translation, there remains a need to...
6.
Kuhlmann I, Hjelmar Petersen R, Overgaard M, de la Cour K, Zwisler S, Stage T, et al.
Basic Clin Pharmacol Toxicol
. 2021 Oct;
130(1):93-102.
PMID: 34599645
We investigated the impact of genetic variants in OCT1 (SLC22A1) on morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) pharmacokinetics in adult patients scheduled for major surgery. Blood samples were taken before...
7.
Rittig N, Aagaard N, Sundelin E, Villadsen G, Sandahl T, Holst J, et al.
Clin Pharmacol Ther
. 2021 Jul;
110(5):1329-1336.
PMID: 34331316
The pharmacodynamic effects of metformin remain elusive, but several lines of evidence suggest a critical role of direct effects in the gastrointestinal (GI) tract. We investigated if metformin stimulates intestinal...
8.
Kuhlmann I, Noddebo Nyrup A, Stage T, Christensen M, Bergmann T, Damkier P, et al.
Clin Transl Sci
. 2021 Jul;
14(6):2408-2419.
PMID: 34268884
The aim of the study was to investigate if there is a clinically relevant drug interaction between metformin and codeine. Volunteers were randomized to receive on four separate occasions: (A)...
9.
Frederiksen T, Areberg J, Schmidt E, Stage T, Brosen K
CPT Pharmacometrics Syst Pharmacol
. 2021 May;
10(9):983-993.
PMID: 33932135
The cytochrome P450 (CYP) 2D6 enzyme exhibits large interindividual differences in metabolic activity. Patients are commonly assigned a CYP2D6 phenotype based on their CYP2D6 genotype, but there is a lack...
10.