Kieran A Brune
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Explore the profile of Kieran A Brune including associated specialties, affiliations and a list of published articles.
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10
Citations
874
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Recent Articles
1.
Nishida K, Brune K, Putcha N, Mandke P, ONeal W, Shade D, et al.
Am J Physiol Lung Cell Mol Physiol
. 2017 Jun;
313(3):L581-L591.
PMID: 28642260
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Cigarette smoke (CS) drives disease development and progression. The epithelial barrier is damaged by CS with increased...
2.
HIV Impairs Lung Epithelial Integrity and Enters the Epithelium to Promote Chronic Lung Inflammation
Brune K, Ferreira F, Mandke P, Chau E, Aggarwal N, DAlessio F, et al.
PLoS One
. 2016 Mar;
11(3):e0149679.
PMID: 26930653
Several clinical studies show that individuals with HIV are at an increased risk for worsened lung function and for the development of COPD, although the mechanism underlying this increased susceptibility...
3.
Axilbund J, Brune K, Canto M, Brehon B, Wroblewski L, Griffin C
Hered Cancer Clin Pract
. 2010 Mar;
3(3):115-22.
PMID: 20223036
Purpose: To assess patient views regarding the value of genetic counselling for familial pancreas cancer in the absence of predictive genetic testing. Patients And Methods: At-risk adults with three or...
4.
Brune K, Lau B, Palmisano E, Canto M, Goggins M, Hruban R, et al.
J Natl Cancer Inst
. 2010 Jan;
102(2):119-26.
PMID: 20068195
Background: Young-onset cancer is a hallmark of many familial cancer syndromes, yet the implications of young-onset disease in predicting risk of pancreatic cancer among familial pancreatic cancer (FPC) kindred members...
5.
Wang L, Brune K, Visvanathan K, Laheru D, Herman J, Wolfgang C, et al.
Cancer Epidemiol Biomarkers Prev
. 2009 Oct;
18(11):2829-34.
PMID: 19843679
Most inherited cancer syndromes are characterized by the familial clustering of cancers at several organ sites. To determine if cancers, other than pancreatic cancer, cluster in pancreatic cancer kindreds, we...
6.
Axilbund J, Argani P, Kamiyama M, Palmisano E, Raben M, Borges M, et al.
Cancer Biol Ther
. 2008 Nov;
8(2):131-5.
PMID: 19029836
Recent studies have suggested that germ line mutations in the BRCA1 gene may confer an increased risk of developing pancreatic cancer. To determine if BRCA1 mutations explain a significant proportion...
7.
Wang W, Chen S, Brune K, Hruban R, Parmigiani G, Klein A
J Clin Oncol
. 2007 Apr;
25(11):1417-22.
PMID: 17416862
Purpose: The rapid fatality of pancreatic cancer is, in large part, the result of an advanced stage of diagnosis for the majority of patients. Identification of individuals at high risk...
8.
Klein A, Brune K, Petersen G, Goggins M, Tersmette A, Offerhaus G, et al.
Cancer Res
. 2004 Apr;
64(7):2634-8.
PMID: 15059921
Individuals with a family history of pancreatic cancer have an increased risk of developing pancreatic cancer. Quantification of this risk provides a rational basis for cancer risk counseling and for...
9.
Klein A, Beaty T, Bailey-Wilson J, Brune K, Hruban R, Petersen G
Genet Epidemiol
. 2002 Sep;
23(2):133-49.
PMID: 12214307
Family history of pancreatic cancer, the fifth leading cause of cancer death in the United States, confers a 1.5-13-fold higher risk of developing pancreatic cancer. Pancreatic cancer is associated with...
10.
Murphy K, Brune K, Griffin C, Sollenberger J, Petersen G, Bansal R, et al.
Cancer Res
. 2002 Jul;
62(13):3789-93.
PMID: 12097290
It is estimated that familial aggregation and genetic susceptibility play a role in as many as 10% of pancreatic ductal adenocarcinomas. To investigate the role of germ-line mutations in the...