Kiarash Shamardani
Overview
Explore the profile of Kiarash Shamardani including associated specialties, affiliations and a list of published articles.
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14
Citations
567
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Recent Articles
1.
Barron T, Yalcin B, Su M, Byun Y, Gavish A, Shamardani K, et al.
Nature
. 2025 Feb;
PMID: 39972132
High-grade gliomas (HGGs) are the leading cause of brain cancer-related death. HGGs include clinically, anatomically and molecularly distinct subtypes that stratify into diffuse midline gliomas (DMGs), such as H3K27M-altered diffuse...
2.
Drexler R, Drinnenberg A, Gavish A, Yalcin B, Shamardani K, Rogers A, et al.
bioRxiv
. 2024 Oct;
PMID: 39386427
Neuronal activity promotes the proliferation of healthy oligodendrocyte precursor cells (OPC) and their malignant counterparts, gliomas. Many gliomas arise from and closely resemble oligodendroglial lineage precursors, including diffuse midline glioma...
3.
Yalcin B, Pomrenze M, Malacon K, Drexler R, Rogers A, Shamardani K, et al.
Nature
. 2024 Jun;
630(8017):677-685.
PMID: 38839962
All drugs of abuse induce long-lasting changes in synaptic transmission and neural circuit function that underlie substance-use disorders. Another recently appreciated mechanism of neural circuit plasticity is mediated through activity-regulated...
4.
Geraghty A, Acosta-Alvarez L, Rotiroti M, Dutton S, ODea M, Woo P, et al.
bioRxiv
. 2024 May;
PMID: 38798554
Persistent central nervous system (CNS) immune dysregulation and consequent dysfunction of multiple neural cell types is central to the neurobiological underpinnings of a cognitive impairment syndrome that can occur following...
5.
Scala J, Cha H, Shamardani K, Rashes E, Acosta-Alvarez L, Mediratta R
BMC Med Educ
. 2024 Apr;
24(1):426.
PMID: 38649984
Background: Medical school curricula strive to train community-engaged and culturally competent physicians, and many use service learning to instill these values in students. The current standards for medical service learning...
6.
Oldenburg I, Hendricks W, Handy G, Shamardani K, Bounds H, Doiron B, et al.
Nat Neurosci
. 2024 Jan;
27(1):137-147.
PMID: 38172437
Recurrent cortical activity sculpts visual perception by refining, amplifying or suppressing visual input. However, the rules that govern the influence of recurrent activity remain enigmatic. We used ensemble-specific two-photon optogenetics...
7.
Taylor K, Barron T, Hui A, Spitzer A, Yalcin B, Ivec A, et al.
Nature
. 2023 Nov;
623(7986):366-374.
PMID: 37914930
The role of the nervous system in the regulation of cancer is increasingly appreciated. In gliomas, neuronal activity drives tumour progression through paracrine signalling factors such as neuroligin-3 and brain-derived...
8.
Shamardani K, Monje M
Cancer Cell
. 2023 Aug;
41(9):1541-1543.
PMID: 37652004
Brain metastases cause cognitive impairment and impair quality of life. Sanchez-Aguilera et al. examine the effects of metastases on brain function leveraging in vivo electrocorticography and machine learning to reveal...
9.
Krishna S, Choudhury A, Keough M, Seo K, Ni L, Kakaizada S, et al.
Nature
. 2023 May;
617(7961):599-607.
PMID: 37138086
Gliomas synaptically integrate into neural circuits. Previous research has demonstrated bidirectional interactions between neurons and glioma cells, with neuronal activity driving glioma growth and gliomas increasing neuronal excitability. Here we...
10.
Fernandez-Castaneda A, Lu P, Geraghty A, Song E, Lee M, Wood J, et al.
Cell
. 2022 Jun;
185(14):2452-2468.e16.
PMID: 35768006
COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. Here, we explored the...