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Khanh D Huynh

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Articles 7
Citations 623
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Recent Articles
1.
Namekawa S, Payer B, Huynh K, Jaenisch R, Lee J
Mol Cell Biol . 2010 Apr; 30(13):3187-205. PMID: 20404085
Mammals compensate for unequal X-linked gene dosages between the sexes by inactivating one X chromosome in the female. In marsupials and in the early mouse embryo, X chromosome inactivation (XCI)...
2.
Zhang L, Huynh K, Lee J
Cell . 2007 May; 129(4):693-706. PMID: 17512404
In mammalian females, two X chromosomes are epigenetically distinguished as active and inactive chromosomes to balance X-linked gene dosages between males and females. How the Xs are maintained differently in...
3.
Lewis A, Green K, Dawson C, Redrup L, Huynh K, Lee J, et al.
Development . 2006 Oct; 133(21):4203-10. PMID: 17021040
The mouse Kcnq1 imprinted domain is located on distal chromosome 7 and contains several imprinted genes that are paternally repressed. Repression of these genes is regulated by a non-coding antisense...
4.
Boumil R, Ogawa Y, Sun B, Huynh K, Lee J
Mol Cell Biol . 2006 Mar; 26(6):2109-17. PMID: 16507990
During mammalian dosage compensation, one of two X-chromosomes in female cells is inactivated. The choice of which X is silenced can be imprinted or stochastic. Although genetic loci influencing the...
5.
Huynh K, Lee J
Nat Rev Genet . 2005 Apr; 6(5):410-8. PMID: 15818384
In mammals, sex is determined by differential inheritance of a pair of dimorphic chromosomes: the gene-rich X chromosome and the gene-poor Y chromosome. To balance the unequal X-chromosome dosage between...
6.
Huynh K, Lee J
Nature . 2003 Dec; 426(6968):857-62. PMID: 14661031
In mammals, dosage compensation ensures equal X-chromosome expression between males (XY) and females (XX) by transcriptionally silencing one X chromosome in XX embryos. In the prevailing view, the XX zygote...
7.
Chao W, Huynh K, Spencer R, Davidow L, Lee J
Science . 2001 Dec; 295(5553):345-7. PMID: 11743158
In mammals, X-inactivation silences one of two female X chromosomes. Silencing depends on the noncoding gene, Xist (inactive X-specific transcript), and is blocked by the antisense gene, Tsix. Deleting the...