Khadijah Edueng
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Explore the profile of Khadijah Edueng including associated specialties, affiliations and a list of published articles.
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10
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58
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Recent Articles
1.
Alvebratt C, Karlen F, Ahlen M, Edueng K, Dubbelboer I, Bergstrom C
Int J Pharm
. 2024 Jul;
663:124437.
PMID: 39002818
A variety of enabling formulations has been developed to address poor oral drug absorption caused by insufficient dissolution in the gastrointestinal tract. As the in vivo performance of these formulations...
2.
Edueng K, Kabedev A, Ekdahl A, Mahlin D, Baumann J, Mudie D, et al.
Int J Pharm
. 2021 Dec;
613:121360.
PMID: 34896563
Robust and reliable in vivo performance of medicines based on amorphous solid dispersions (ASDs) depend on maintenance of physical stability and efficient supersaturation. However, molecular drivers of these two kinetic...
3.
Alvebratt C, Keemink J, Edueng K, Cheung O, Stromme M, Bergstrom C
Eur J Pharm Biopharm
. 2020 Jan;
149:21-29.
PMID: 31982572
Advanced drug delivery systems (ADDS) are widely explored to overcome poor aqueous solubility of orally administered drugs. However, the prediction of their in vivo performance is challenging, as in vitro...
4.
Edueng K, Bergstrom C, Grasjo J, Mahlin D
Pharmaceutics
. 2019 Aug;
11(9).
PMID: 31438566
This study shows the importance of the chosen method for assessing the glass-forming ability (GFA) and glass stability (GS) of a drug compound. Traditionally, GFA and GS are established using...
5.
Edueng K, Mahlin D, Grasjo J, Nylander O, Thakrani M, Bergstrom C
Molecules
. 2019 Jul;
24(15).
PMID: 31357587
This study explores the effect of physical aging and/or crystallization on the supersaturation potential and crystallization kinetics of amorphous active pharmaceutical ingredients (APIs). Spray-dried, fully amorphous indapamide, metolazone, glibenclamide, hydrocortisone,...
6.
Ahmad K, Win T, Md Jaffri J, Edueng K, Taher M
AAPS PharmSciTech
. 2017 Jul;
19(1):371-383.
PMID: 28744617
This study aims to investigate the use of palm olein as the oil phase for betamethasone 17-valerate (BV) emulsions. The physicochemical properties of the formulations were characterized. In vitro drug...
7.
Edueng K, Mahlin D, Bergstrom C
Pharm Res
. 2017 May;
34(9):1754-1772.
PMID: 28523384
The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of the attractive approaches to enhance solubility is via amorphization...
8.
Edueng K, Mahlin D, Larsson P, Bergstrom C
J Control Release
. 2017 Apr;
256:193-202.
PMID: 28412224
We developed a step-by-step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and a small-scale dissolution apparatus (μDISS Profiler) to investigate the mechanism...
9.
Andersson S, Alvebratt C, Bevernage J, Bonneau D, Mathews C, Dattani R, et al.
J Pharm Sci
. 2016 Apr;
105(9):2864-2872.
PMID: 27112289
The purpose of this study was to investigate the interlaboratory variability in determination of apparent solubility (Sapp) and intrinsic dissolution rate (IDR) using a miniaturized dissolution instrument. Three poorly water-soluble...
10.
Taher M, Susanti D, Abd Hamid S, Edueng K, Md Jaffri J, Adina A, et al.
Pak J Pharm Sci
. 2013 Dec;
27(1):179-81.
PMID: 24374446
An alkaloid from Maclurodendron porteri has been isolated and characterized. Extraction process was conducted by acid-base extraction method followed by column chromatography. The structure was established by nuclear magnetic resonance...