Kevin T Ebata
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Explore the profile of Kevin T Ebata including associated specialties, affiliations and a list of published articles.
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12
Citations
987
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Recent Articles
1.
DiTroia S, Percharde M, Guerquin M, Wall E, Collignon E, Ebata K, et al.
Nature
. 2019 Nov;
576(7785):E1.
PMID: 31719689
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
2.
DiTroia S, Percharde M, Guerquin M, Wall E, Collignon E, Ebata K, et al.
Nature
. 2019 Sep;
573(7773):271-275.
PMID: 31485074
Development is often assumed to be hardwired in the genome, but several lines of evidence indicate that it is susceptible to environmental modulation with potential long-term consequences, including in mammals....
3.
Laetsch T, Dubois S, Mascarenhas L, Turpin B, Federman N, Albert C, et al.
Lancet Oncol
. 2018 Apr;
19(5):705-714.
PMID: 29606586
Background: Gene fusions involving NTRK1, NTRK2, or NTRK3 (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective small-molecule inhibitor of the TRK...
4.
Ebata K, Mesh K, Liu S, Bilenky M, Fekete A, Acker M, et al.
Epigenetics Chromatin
. 2017 Jul;
10:36.
PMID: 28706564
Background: Histone methylation patterns regulate gene expression and are highly dynamic during development. The erasure of histone methylation is carried out by histone demethylase enzymes. We had previously shown that...
5.
Blaschke K, Ebata K, Karimi M, Zepeda-Martinez J, Goyal P, Mahapatra S, et al.
Nature
. 2013 Jul;
500(7461):222-6.
PMID: 23812591
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in the early embryo and the germ line, and...
6.
Sachs M, Onodera C, Blaschke K, Ebata K, Song J, Ramalho-Santos M
Cell Rep
. 2013 Jun;
3(6):1777-84.
PMID: 23727241
Developmental regulatory genes have both activating (H3K4me3) and repressive (H3K27me3) histone modifications in embryonic stem cells (ESCs). This bivalent configuration is thought to maintain lineage commitment programs in a poised...
7.
Ebata K, Yeh J, Zhang X, Nagano M
Exp Cell Res
. 2011 Mar;
317(10):1319-29.
PMID: 21420950
Spermatogonial stem cells (SSCs) support life-long spermatogenesis by self-renewing and producing spermatogonia committed to differentiation. In vitro, SSCs form three-dimensional spermatogonial aggregates (clusters) when cultured with glial cell line-derived neurotrophic...
8.
Ebata K, Yeh J, Zhang X, Nagano M
Dis Markers
. 2008 Jun;
24(4-5):267-76.
PMID: 18525121
Spermatogonial stem cells (SSCs) are defined by their ability to both self-renew and produce differentiated germ cells that will develop into functional spermatozoa. Because of this ability, SSCs can reestablish...
9.
Ebata K, Zhang X, Nagano M
Biol Reprod
. 2007 Jan;
76(5):841-7.
PMID: 17229930
Spermatogonial stem cells (SSCs) continuously support spermatogenesis after puberty. However, accumulating evidence suggests that SSCs differ functionally during postnatal development. For example, mutant mice exist in which SSCs support spermatogenesis...
10.
Zhang X, Ebata K, Robaire B, Nagano M
Biol Reprod
. 2005 Sep;
74(1):119-24.
PMID: 16177220
In the present study, we investigated the effect of aging on spermatogonial stem cells (SSCs) and on the testicular somatic environment in ROSA26 mice. First, we examined testis weights at...