Kevin Sinchak
Overview
Explore the profile of Kevin Sinchak including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1068
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Recent Articles
1.
Chuon T, Feri M, Carlson C, Ondrejik S, Micevych P, Sinchak K
J Neuroendocrinol
. 2021 Dec;
34(1):e13071.
PMID: 34904297
Neural circuits in female rats are exposed to sequential estradiol and progesterone to regulate the release of luteinizing hormone (LH) and ultimately ovulation. Estradiol induces progesterone receptors (PGRs) in anteroventral...
2.
Sinchak K, Mohr M, Micevych P
Front Endocrinol (Lausanne)
. 2020 Jul;
11:420.
PMID: 32670203
Neural circuits in female rats sequentially exposed to estradiol and progesterone underlie so-called estrogen positive feedback that induce the surge release of pituitary luteinizing hormone (LH) leading to ovulation and...
3.
Tominna R, Chokr S, Feri M, Chuon T, Sinchak K
Horm Behav
. 2019 Apr;
112:89-99.
PMID: 30981690
In estradiol-primed nonreceptive ovariectomized rats, activation of G protein-coupled estrogen receptor 1 (GPER) in the arcuate nucleus of the hypothalamus (ARH) rapidly facilitates sexual receptivity (lordosis). Estradiol priming activates ARH...
4.
5.
Micevych P, Mermelstein P, Sinchak K
Trends Neurosci
. 2017 Oct;
40(11):654-666.
PMID: 28969926
Over the past few years our understanding of estrogen signaling in the brain has expanded rapidly. Estrogens are synthesized in the periphery and in the brain, acting on multiple receptors...
6.
Long N, Long B, Mana A, Le D, Nguyen L, Chokr S, et al.
Horm Behav
. 2017 Jan;
89:98-103.
PMID: 28063803
In the female rat, sexual receptivity (lordosis) can be facilitated by sequential activation of estrogen receptor (ER) α and G protein-coupled estrogen receptor 1 (GPER) by estradiol. In the estradiol...
7.
Rudolph L, Cornil C, Mittelman-Smith M, Rainville J, Remage-Healey L, Sinchak K, et al.
J Neurosci
. 2016 Dec;
36(45):11449-11458.
PMID: 27911748
Over the past two decades, the classical understanding of steroid action has been updated to include rapid, membrane-initiated, neurotransmitter-like functions. While steroids were known to function on very short time...
8.
Conde K, Meza C, Kelly M, Sinchak K, Wagner E
Neuroendocrinology
. 2016 Jan;
103(6):787-805.
PMID: 26765570
Estradiol rapidly regulates the activity of arcuate nucleus (ARH) proopiomelanocortin (POMC) neurons that project to the medial preoptic nucleus (MPN) to regulate lordosis. Orphanin FQ/nociceptin (OFQ/N) acts via opioid receptor-like...
9.
Sinchak K, Dalhousay L, Sanathara N
Vitam Horm
. 2015 Feb;
97:187-221.
PMID: 25677773
Orphanin FQ (OFQ/N) and its receptor, opioid receptor-like receptor-1 (ORL-1), are expressed throughout steroid-responsive limbic and hypothalamic circuits that regulate female ovarian hormone feedback and reproductive behavior circuits. The arcuate...
10.
Long N, Serey C, Sinchak K
Horm Behav
. 2014 Sep;
66(4):663-6.
PMID: 25245158
In female rats sexual receptivity (lordosis) can be induced with either a single large dose of estradiol benzoate (EB), or a priming dose of EB that does not induce sexual...