Kevin M Wright
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Explore the profile of Kevin M Wright including associated specialties, affiliations and a list of published articles.
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63
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1441
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Recent Articles
1.
Mullis M, Wright K, Raj A, Gatti D, Reifsnyder P, Flurkey K, et al.
bioRxiv
. 2024 Nov;
PMID: 39605744
Lifespan is an integrative phenotype whose genetic architecture is likely to highlight multiple processes with high impact on health and aging. Here, we conduct a genetic meta-analysis of longevity in...
2.
Co M, OBrien G, Wright K, ORoak B
Autism Res
. 2024 Nov;
PMID: 39548698
Cre recombinase knock-in mouse lines have served as invaluable genetic tools for understanding key developmental processes altered in autism. However, insertion of exogenous DNA into the genome can have unintended...
3.
Di Francesco A, Deighan A, Litichevskiy L, Chen Z, Luciano A, Robinson L, et al.
Nature
. 2024 Oct;
634(8034):684-692.
PMID: 39385029
Caloric restriction extends healthy lifespan in multiple species. Intermittent fasting, an alternative form of dietary restriction, is potentially more sustainable in humans, but its effectiveness remains largely unexplored. Identifying the...
4.
Jahncke J, Schnell E, Wright K
bioRxiv
. 2024 Sep;
PMID: 39257744
Dystroglycan is a cell adhesion molecule that localizes to synapses throughout the nervous system. While Dystroglycan is required to maintain inhibitory synapses from cerebellar molecular layer interneurons (MLIs) onto Purkinje...
5.
Tools for -Mediated Conditional Deletion of Floxed Alleles from Developing Cerebellar Purkinje Cells
Jahncke J, Wright K
eNeuro
. 2024 May;
11(6).
PMID: 38777609
The Cre-lox system is an indispensable tool in neuroscience research for targeting gene deletions to specific cellular populations. Here we assess the utility of several transgenic lines, along with a...
6.
Co M, OBrien G, Wright K, ORoak B
bioRxiv
. 2024 Apr;
PMID: 38617321
Spatiotemporal control of Cre-mediated recombination has been an invaluable tool for understanding key developmental processes. For example, knock-in of into cell type marker gene loci drives expression under endogenous promoter...
7.
Tools for -mediated conditional deletion of floxed alleles from developing cerebellar Purkinje cells
Jahncke J, Wright K
bioRxiv
. 2024 Apr;
PMID: 38585758
The Cre-lox system is an indispensable tool in neuroscience research for targeting gene deletions to specific cellular populations. Here we assess the utility of several transgenic lines, along with a...
8.
Jahncke J, Miller D, Krush M, Schnell E, Wright K
Elife
. 2024 Jan;
12.
PMID: 38179984
Dystroglycan (Dag1) is a transmembrane glycoprotein that links the extracellular matrix to the actin cytoskeleton. Mutations in or the genes required for its glycosylation result in dystroglycanopathy, a type of...
9.
Fernandez A, Sarn N, Eng C, Wright K
bioRxiv
. 2023 Oct;
PMID: 37781577
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social interactions, repetitive behaviors, and hyper- or hyposensitivity to sensory stimuli. The mechanisms underlying the emergence of...
10.
Kerstein P, Agreda Y, Curran B, Ma L, Wright K
bioRxiv
. 2023 Aug;
PMID: 37577554
Within the neuronal classes of the retina, amacrine cells (ACs) exhibit the greatest neuronal diversity in morphology and function. We show that the selective expression of the transcription factor is...