Kevin J Crowell
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Explore the profile of Kevin J Crowell including associated specialties, affiliations and a list of published articles.
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9
Citations
113
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Recent Articles
1.
Leone M, Crowell K, Chen J, Jung D, Chiang G, Sareth S, et al.
Biochemistry
. 2006 Aug;
45(34):10294-302.
PMID: 16922504
The mammalian target of rapamycin (mTOR) is a protein that is intricately involved in signaling pathways controlling cell growth. Rapamycin is a natural product that binds and inhibits mTOR function...
2.
Becattini B, Culmsee C, Leone M, Zhai D, Zhang X, Crowell K, et al.
Proc Natl Acad Sci U S A
. 2006 Aug;
103(33):12602-6.
PMID: 16891420
Bcl-2 family proteins play a crucial role in tissue homeostasis and apoptosis (programmed cell death). Bid is a proapoptotic member of the Bcl-2 family, promoting cell death when activated by...
3.
MacKinnon N, Ridgway J, Crowell K, Macdonald P
Chem Phys Lipids
. 2005 Dec;
139(2):85-95.
PMID: 16336955
Two-dimensional (2D) (31)P magic angle spinning (MAS) nuclear magnetic resonance (NMR) exchange spectroscopy (EXSY) demonstrated that aluminum binds to the phosphate group of phosphatidylcholine (PC) in multilamellar vesicles at pH...
4.
Fattorusso R, Jung D, Crowell K, Forino M, Pellecchia M
J Med Chem
. 2005 Mar;
48(5):1649-56.
PMID: 15743206
In this paper, we report a simple structure-based iterative optimizations (SUBITO) strategy to identify and optimize new protein ligands and inhibitors. The approach is based on a combination of NMR-based...
5.
Pellecchia M, Becattini B, Crowell K, Fattorusso R, Forino M, Fragai M, et al.
Expert Opin Ther Targets
. 2004 Dec;
8(6):597-611.
PMID: 15584865
In this review, the use of general NMR spectroscopy techniques to detect ligand binding and to monitor enzyme kinetics and inhibition, which appear particularly useful in hit identification and validation,...
6.
MacKinnon N, Crowell K, Udit A, Macdonald P
Chem Phys Lipids
. 2004 Nov;
132(1):23-36.
PMID: 15530445
27Al and 31P nuclear magnetic resonance (NMR) spectroscopies were used to investigate aluminum interactions at pH 3.4 with model membranes composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). A solution state 27Al NMR difference...
7.
Becattini B, Sareth S, Zhai D, Crowell K, Leone M, Reed J, et al.
Chem Biol
. 2004 Aug;
11(8):1107-17.
PMID: 15324812
Bid is a key member of the Bcl-2 family proteins involved in the control of the apoptotic cascade in cells, leading to cell death. Uncontrolled cell death is associated with...
8.
Marassi F, Crowell K
J Magn Reson
. 2003 Mar;
161(1):64-9.
PMID: 12660112
The preparation of oriented, hydration-optimized lipid bilayer samples, for NMR structure determination of membrane proteins, is described. The samples consist of planar phospholipid bilayers, containing membrane proteins, that are oriented...
9.
Crowell K, Franzin C, Koltay A, Lee S, Lucchese A, Snyder B, et al.
Biochim Biophys Acta
. 2003 Jan;
1645(1):15-21.
PMID: 12535606
The proteins PLM (phospholemman), CHIF (channel inducing factor), and Mat8 (mammary tumor protein 8 kDa) are members of the FXYD family of ion transport regulatory membrane proteins. Here we describe...