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Kevin C F Fone

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Articles 51
Citations 1441
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Recent Articles
1.
Goh J, Rueda P, Taylor J, Rathbone A, Scott D, Langmead C, et al.
Neurobiol Stress . 2024 Nov; 33:100679. PMID: 39502833
Social isolation is an established risk factor for psychiatric illness, and became increasingly topical with the spread of SARS-CoV-2. We used RNA sequencing (RNA-Seq) to enable unbiased assessment of transcriptomic...
2.
Wong S, Brown A, Abrahams A, Nurzak A, Eltaher H, Sykes D, et al.
Pharmaceutics . 2024 Oct; 16(10). PMID: 39458599
Methods: The current research used in vitro assays for a novel exploration of PLR's ability to improve the transport of two contrasting peptides, insulin (51 residues, net negative charge) and...
3.
Learoyd A, Calmus R, Cunningham C, England T, Farr T, Fone K, et al.
Wellcome Open Res . 2021 Jun; 6:104. PMID: 34095511
Animal models of stroke have been criticised as having poor predictive validity, lacking risk factors prevalent in an aging population. This pilot study examined the development of comorbidities in a...
4.
Millan M, Dekeyne A, Gobert A, Brocco M, Mannoury la Cour C, Ortuno J, et al.
Neuropharmacology . 2020 Jun; 177:108099. PMID: 32525060
To date, there are no interventions that impede the inexorable progression of Alzheimer's disease (AD), and currently-available drugs cholinesterase (AChE) inhibitors and the N-Methyl-d-Aspartate receptor antagonist, memantine, offer only modest...
5.
Goh J, OSullivan S, Shortall S, Zordan N, Piccinini A, Potter H, et al.
Brain Behav Immun . 2020 Jun; 89:100-117. PMID: 32485291
Many psychiatric illnesses have a multifactorial etiology involving genetic and environmental risk factors that trigger persistent neurodevelopmental impairments. Several risk factors have been individually replicated in rodents, to understand disease...
6.
Fone K, Watson D, Billiras R, Sicard D, Dekeyne A, Rivet J, et al.
Mol Neurobiol . 2020 Jan; 57(5):2144-2166. PMID: 31960362
Frontocortical NMDA receptors are pivotal in regulating cognition and mood, are hypofunctional in schizophrenia, and may contribute to autistic spectrum disorders. Despite extensive interest in agents potentiating activity at the...
7.
Marshall H, Pezze M, Fone K, Cassaday H
Neurobiol Learn Mem . 2019 Jul; 164:107041. PMID: 31351120
Appetitive trace conditioning (TC) was examined over 6 months in younger-adult (2-8 months) and middle-aged (12-18 months) male Wistar RccHan rats, to test for early age-related impairment in working memory....
8.
Kohli S, King M, Williams S, Edwards A, Ballard T, Steward L, et al.
Neuropsychopharmacology . 2018 Aug; 44(2):295-305. PMID: 30120410
The pituitary neuropeptide oxytocin promotes social behavior, and is a potential adjunct therapy for social deficits in schizophrenia and autism. Oxytocin may mediate pro-social effects by modulating monoamine release in...
9.
Dunphy-Doherty F, OMahony S, Peterson V, OSullivan O, Crispie F, Cotter P, et al.
Brain Behav Immun . 2017 Nov; 68:261-273. PMID: 29104061
Early-life stress is an established risk for the development of psychiatric disorders. Post-weaning isolation rearing of rats produces lasting developmental changes in behavior and brain function that may have translational...
10.
Watson D, King M, Gyertyan I, Kiss B, Adham N, Fone K
Eur Neuropsychopharmacol . 2016 Jan; 26(2):208-224. PMID: 26723167
Current antipsychotic medication is largely ineffective against the negative and cognitive symptoms of schizophrenia. One promising therapeutic development is to design new molecules that balance actions on dopamine D2 and...