Kevin A Goncalves
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Explore the profile of Kevin A Goncalves including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
312
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Recent Articles
1.
Schneider R, Mansour B, Kolvenbach C, Buerger F, Salmanullah D, Lemberg K, et al.
J Nephrol
. 2024 Aug;
37(6):1723.
PMID: 39115675
No abstract available.
2.
Schneider R, Mansour B, Kolvenbach C, Buerger F, Salmanullah D, Lemberg K, et al.
J Nephrol
. 2024 Jul;
38(1):143-152.
PMID: 39003671
Background: Steroid-resistant nephrotic syndrome (SRNS) is the second most frequent cause of chronic kidney disease in children and young adults. The most severe form of steroid-resistant nephrotic syndrome is congenital...
3.
Lemberg K, Mertens N, Yousef K, Schneider R, Merz L, Mansour B, et al.
Sci Rep
. 2024 Jul;
14(1):15916.
PMID: 38987283
Steroid-resistant nephrotic syndrome (SRNS) is the second most frequent cause of childhood chronic kidney disease. Congenital nephrotic syndrome of the Finnish type (CNF) (MIM# 256300) is caused by biallelic variants...
4.
Buerger F, Merz L, Saida K, Yu S, Salmanullah D, Lemberg K, et al.
Am J Physiol Renal Physiol
. 2024 Mar;
326(5):F780-F791.
PMID: 38482553
Steroid-resistant nephrotic syndrome (SRNS) is the second most frequent cause of chronic kidney disease before the age of 25 yr. Nephrin, encoded by localizes to the slit diaphragm of glomerular...
5.
Yang H, Yuan L, Ibaragi S, Li S, Shapiro R, Vanli N, et al.
Br J Cancer
. 2022 Apr;
127(3):422-435.
PMID: 35418212
Background: Angiogenin is a multifunctional secreted ribonuclease that is upregulated in human cancers and downregulated or mutationally inactivated in neurodegenerative diseases. A role for angiogenin in glioblastoma was inferred from...
6.
Li C, Goncalves K, Rasko T, Pande A, Gil S, Liu Z, et al.
Blood Adv
. 2021 Mar;
5(5):1239-1249.
PMID: 33646305
We have developed an in vivo hemopoietic stem cell (HSC) gene therapy approach without the need for myelosuppressive conditioning and autologous HSC transplantation. It involves HSC mobilization and IV injection...
7.
Li S, Goncalves K, Lyu B, Yuan L, Hu G
Commun Biol
. 2020 Jan;
3(1):26.
PMID: 31942000
Cancer stem cells (CSCs) are an obstacle in cancer therapy and are a major cause of drug resistance, cancer recurrence, and metastasis. Available treatments, targeting proliferating cancer cells, are not...
8.
Yu W, Goncalves K, Li S, Kishikawa H, Sun G, Yang H, et al.
Cell
. 2017 Nov;
171(4):849-864.e25.
PMID: 29100074
Angiogenin (ANG) is a secreted ribonuclease (RNase) with cell-type- and context-specific roles in growth, survival, and regeneration. Although these functions require receptor-mediated endocytosis and appropriate subcellular localization, the identity of...
9.
Silberstein L, Goncalves K, Kharchenko P, Turcotte R, Kfoury Y, Mercier F, et al.
Cell Stem Cell
. 2016 Aug;
19(4):530-543.
PMID: 27524439
Physiological stem cell function is regulated by secreted factors produced by niche cells. In this study, we describe an unbiased approach based on the differential single-cell gene expression analysis of...
10.
Goncalves K, Silberstein L, Li S, Severe N, Hu M, Yang H, et al.
Cell
. 2016 Aug;
166(4):894-906.
PMID: 27518564
Regulation of stem and progenitor cell populations is critical in the development, maintenance, and regeneration of tissues. Here, we define a novel mechanism by which a niche-secreted RNase, angiogenin (ANG),...