Keun Koo Shin
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Explore the profile of Keun Koo Shin including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
298
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Recent Articles
1.
Cho S, Shin K, Kim S, Cho M, Oh D, Lim Y
Tissue Eng Regen Med
. 2022 Apr;
19(5):1099-1111.
PMID: 35460494
Background: Bone marrow-derived mesenchymal stem cells (BMSCs) and bone morphogenetic protein-2 (BMP-2) have been studied for bone repair because they have regenerative potential to differentiate into osteoblasts. The development of...
2.
Cha E, Shin K, Seo J, Oh D
BMB Rep
. 2020 May;
53(8):442-447.
PMID: 32438971
The non-viral delivery of genes into macrophages, known as hard-to-transfect cells, is a challenge. In this study, the microporation of a CpG-free and small plasmid (pCGfd-GFP) showed high transfection efficiency,...
3.
Kang J, Shin K, Kim H, Min J, Ji E, Kim J, et al.
Sci Rep
. 2018 Jun;
8(1):8730.
PMID: 29880804
Many therapeutic enzymes for lysosomal storage diseases require a high content of mannose-6-phosphate (M6P) glycan, which is important for cellular uptake and lysosomal targeting. We constructed glyco-engineered yeast harboring a...
4.
Kim Y, Kang J, Gil J, Kim S, Shin K, Kang H, et al.
Appl Microbiol Biotechnol
. 2017 Jan;
101(7):2979-2989.
PMID: 28101612
Mannosylphosphorylated glycans are found only in fungi, including yeast, and the elimination of mannosylphosphates from glycans is a prerequisite for yeast glyco-engineering to produce human-compatible glycoproteins. In Saccharomyces cerevisiae, MNN4...
5.
Mun J, Shin K, Kwon O, Lim Y, Oh D
Biomaterials
. 2016 Jun;
101:310-20.
PMID: 27315214
Genetic engineering approaches to improve the therapeutic potential of mesenchymal stem cells (MSCs) have been made by viral and non-viral gene delivery methods. Viral methods have severe limitations in clinical...
6.
Lee S, Lee J, Shin K, Kim D, Kim Y, Bae Y, et al.
Stem Cells Dev
. 2014 Oct;
24(7):836-45.
PMID: 25350220
Tumor necrosis factor-α (TNF-α) has multiple effects on proliferation and differentiation of human mesenchymal stem cells. Transforming growth factor-activated kinase-1 (TAK1) mediates the activation of nuclear factor-kappa B (NF-κB), c-Jun...
7.
Shin K, Kim Y, Kim J, Bae Y, Jung J
Cell Physiol Biochem
. 2014 Mar;
33(3):758-68.
PMID: 24662459
Background/aims: Demonstrating the molecular mechanisms of human adipose tissue-derived mesenchymal stem cells (hADSCs) differentiation and proliferation could develop hADSCs-based cell therapy. Methods: The microRNA-137 (miR-137) and cell division control protein...
8.
Shin K, Lee A, Kim J, Lee S, Bae Y, Jung J
Biochem Biophys Res Commun
. 2012 May;
422(4):633-8.
PMID: 22609400
Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic...
9.
Kim Y, Hwang S, Lee S, Shin K, Cho H, Bae Y, et al.
Stem Cells Dev
. 2011 Oct;
21(10):1749-60.
PMID: 21988232
The reduction of adult stem cell self-renewal can be an important mechanism of aging. MicroRNAs have been reported to be involved in aging processes. Through a microarray approach, we have...
10.
Kim Y, Hwang S, Cho H, Shin K, Bae Y, Jung J
J Cell Physiol
. 2011 Mar;
227(1):183-93.
PMID: 21381024
A better understanding of the molecular mechanisms that govern human adipose tissue-derived mesenchymal stem cells (hASCs) differentiation could provide new insights into a number of diseases including obesity. Our previous...