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Kerstin Kellner

Explore the profile of Kerstin Kellner including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 165
Followers 0
Related Specialties
Oncology
Allergy & Immunology
Microbiology
Top 10 Co-Authors
Gero Brockhoff
Olaf Ortmann
Christina Bruss
Stephan Seitz
Magdalena Huber
Evita Bothur
Hartmann Raifer
Veruschka Albert
James A Hutchinson
Michael Lohoff
Published In
Cancers (Basel)
Virology
Proc Natl Acad Sci U S A
Neurobiol Stress
Eur J Immunol
Affiliations
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Recent Articles
1.
Neoadjuvant radiotherapy in ER, HER2, and triple-negative -specific breast cancer based humanized tumor mice enhances anti-PD-L1 treatment efficacy
Bruss C, Albert V, Seitz S, Blaimer S, Kellner K, Pohl F, et al.
Front Immunol . 2024 May; 15:1355130. PMID: 38742103
Pre-operative radiation therapy is not currently integrated into the treatment protocols for breast cancer. However, transforming immunological "cold" breast cancers by neoadjuvant irradiation into their "hot" variants is supposed to...
2.
CRF binding protein activity in the hypothalamic paraventricular nucleus is essential for stress adaptations and normal maternal behaviour in lactating rats
Sanson A, Krieg P, Schramm M, Kellner K, Maloumby R, Klampfl S, et al.
Neurobiol Stress . 2024 Apr; 30:100631. PMID: 38601362
To ensure the unrestricted expression of maternal behaviour peripartum, activity of the corticotropin-releasing factor (CRF) system needs to be minimised. CRF binding protein (CRF-BP) might be crucial for this adaptation,...
3.
Immune Checkpoint Profiling in Humanized Breast Cancer Mice Revealed Cell-Specific LAG-3/PD-1/TIM-3 Co-Expression and Elevated PD-1/TIM-3 Secretion
Bruss C, Kellner K, Albert V, Hutchinson J, Seitz S, Ortmann O, et al.
Cancers (Basel) . 2023 May; 15(9). PMID: 37174080
Checkpoint blockade is particularly based on PD-1/PD-L1-inhibiting antibodies. However, an efficient immunological tumor defense can be blocked not only by PD-(L)1 but also by the presence of additional immune checkpoint...
4.
Advanced Immune Cell Profiling by Multiparameter Flow Cytometry in Humanized Patient-Derived Tumor Mice
Bruss C, Kellner K, Ortmann O, Seitz S, Brockhoff G, Hutchinson J, et al.
Cancers (Basel) . 2022 May; 14(9). PMID: 35565343
"Humanized" mice have been widely used for the characterization of human cancer progression and as a powerful preclinical model. Standardization of multicolor phenotyping could help to identify immune cell patterns...
5.
Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22
Raifer H, Mahiny A, Bollig N, Petermann F, Hellhund A, Kellner K, et al.
Eur J Immunol . 2012 Sep; 42(12):3189-201. PMID: 22961652
Apart from conventional CD4(+) Th17 cells, the cytokines IL-17A and IL-22 can also be produced by γδ T cells, NK cells and lymphoid tissue inducer (LTi) cells. Th17 cells develop...
6.
Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation
Bollig N, Brustle A, Kellner K, Ackermann W, Abass E, Raifer H, et al.
Proc Natl Acad Sci U S A . 2012 May; 109(22):8664-9. PMID: 22552227
Follicular T-helper (T(FH)) cells cooperate with GL7(+)CD95(+) germinal center (GC) B cells to induce antibody maturation. Herein, we identify the transcription factor IRF4 as a T-cell intrinsic precondition for T(FH)...
7.
Recruitment of host translation initiation factor eIF4G by the Vaccinia Virus ssDNA-binding protein I3
Zaborowska I, Kellner K, Henry M, Meleady P, Walsh D
Virology . 2012 Jan; 425(1):11-22. PMID: 22280895
Poxviruses are large double-stranded DNA viruses that replicate exclusively in the cytoplasm of infected cells within discrete compartments termed viral factories. Recent work has shown that the prototypical poxvirus, Vaccinia...