Kenneth S Polonsky
Overview
Explore the profile of Kenneth S Polonsky including associated specialties, affiliations and a list of published articles.
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Articles
66
Citations
3604
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Recent Articles
1.
Sun J, Mao L, Polonsky K, Ren D
J Biol Chem
. 2016 May;
291(26):13529-34.
PMID: 27137932
Diabetes develops in Pdx1-haploinsufficient mice due to an increase in β-cell death leading to reduced β-cell mass and decreased insulin secretion. Knockdown of Pdx1 gene expression in mouse MIN6 insulinoma...
2.
Levine A, Alpern R, Andrews N, Antman K, Balser J, Berg J, et al.
Sci Transl Med
. 2015 May;
7(289):289fs22.
PMID: 26019216
Reductions in federal support and clinical revenue jeopardize biomedical research and, in turn, clinical medicine.
3.
Polonsky K, Rubenstein A
Diabetologia
. 2015 Jan;
58(3):419-21.
PMID: 25617020
No abstract available.
4.
Philipson L, Bell G, Polonsky K
Proc Natl Acad Sci U S A
. 2015 Jan;
112(4):940-1.
PMID: 25561547
No abstract available.
5.
Halban P, Polonsky K, Bowden D, Hawkins M, Ling C, Mather K, et al.
Diabetes Care
. 2014 May;
37(6):1751-8.
PMID: 24812433
Objective: This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention...
6.
Ren D, Sun J, Mao L, Ye H, Polonsky K
Diabetes
. 2014 Apr;
63(10):3378-87.
PMID: 24760140
Irs2-deficient mice develop type 2-like diabetes due to a reduction in β-cell mass and a failure of pancreatic islets to undergo compensatory hyperplasia in response to insulin resistance. In order...
7.
Halban P, Polonsky K, Bowden D, Hawkins M, Ling C, Mather K, et al.
J Clin Endocrinol Metab
. 2014 Apr;
99(6):1983-92.
PMID: 24712577
Objective: This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention...
8.
Ren D, Sun J, Wang C, Ye H, Mao L, Cheng E, et al.
Diabetes
. 2014 Mar;
63(8):2744-50.
PMID: 24658302
Mutations in pancreatic duodenal homeobox-1 (PDX1) are associated with diabetes in humans. Pdx1-haploinsufficient mice develop diabetes due to an increase in β-cell death leading to reduced β-cell mass. For definition...
9.
Chowdhury S, Reeds D, Crimmins D, Patterson B, Laciny E, Wang S, et al.
Am J Physiol Gastrointest Liver Physiol
. 2013 Dec;
306(4):G301-9.
PMID: 24356886
Xenin-25 (Xen) is a neurotensin-related peptide secreted by a subset of glucose-dependent insulinotropic polypeptide (GIP)-producing enteroendocrine cells. In animals, Xen regulates gastrointestinal function and glucose homeostasis, typically by initiating neural...
10.
Pedersen M, Mosekilde E, Polonsky K, Luciani D
Biophys J
. 2013 Jul;
105(1):29-39.
PMID: 23823221
Glucose-stimulated insulin secretion is pulsatile and driven by intrinsic oscillations in metabolism, electrical activity, and Ca(2+) in pancreatic islets. Periodic variations in glucose can entrain islet Ca(2+) and insulin secretion,...