Kenneth Lindegaard Madsen
Overview
Explore the profile of Kenneth Lindegaard Madsen including associated specialties, affiliations and a list of published articles.
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16
Citations
108
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Recent Articles
1.
Jensen K, Christensen N, Goddard C, Jager S, Noes-Holt G, Kanneworff I, et al.
JCI Insight
. 2024 Sep;
9(20).
PMID: 39287978
Chronic pain is a complex, debilitating, and escalating health problem worldwide, impacting 1 in 5 adults. Current treatment is compromised by dose-limiting side effects, including high abuse liability, loss of...
2.
Jensen K, Jensen S, Madsen K
Front Pharmacol
. 2022 Sep;
13:854176.
PMID: 36160447
Psychostimulant use disorder is a major health issue around the world with enormous individual, family-related and societal consequences, yet there are no effective pharmacological treatments available. In this review, a...
3.
Sorensen A, Rombach J, Gether U, Madsen K
Cells
. 2022 Apr;
11(8).
PMID: 35455935
Well-tolerated and effective drugs for treating chronic pain conditions are urgently needed. Most chronic pain patients are not effectively relieved from their pain and suffer from debilitating drug side effects....
4.
Christensen N, Pedersen C, Sereikaite V, Pedersen J, Vistrup-Parry M, Sorensen A, et al.
iScience
. 2022 Feb;
25(2):103808.
PMID: 35198873
The organization of the postsynaptic density (PSD), a protein-dense semi-membraneless organelle, is mediated by numerous specific protein-protein interactions (PPIs) which constitute a functional postsynapse. The PSD protein 95 (PSD-95) interacts...
5.
Jensen K, Noes-Holt G, Sorensen A, Madsen K
Front Cell Neurosci
. 2022 Jan;
15:750902.
PMID: 34975407
Chronic pain is a major healthcare problem that impacts one in five adults across the globe. Current treatment is compromised by dose-limiting side effects including drowsiness, apathy, fatigue, loss of...
6.
Erlendsson S, Thorsen T, Madsen K
Bio Protoc
. 2021 Mar;
9(18):e3368.
PMID: 33654865
Studying protein-protein and protein-lipid interactions in their native environment is highly desirable, yet, the heterogeneity and complexity of cellular systems limits the repertoire of experimental methods available. In cells, interactions...
7.
Turner C, De Luca M, Wolfheimer J, Hernandez N, Madsen K, Schmidt H
Neuropharmacology
. 2019 Dec;
164:107901.
PMID: 31805281
Protein interacting with C kinase-1 (PICK1) regulates intra-cellular trafficking of GluA2-containing AMPA receptors, a process known to play a critical role in cocaine-seeking behavior. This suggests that PICK1 may represent...
8.
Hendrik Schmidt J, Perslev M, Bukowski L, Stoklund M, Herborg F, Herlo R, et al.
Basic Clin Pharmacol Toxicol
. 2019 Jun;
126 Suppl 6:116-121.
PMID: 31228220
While the physiological function and mechanisms of agonist-dependent G protein-coupled receptor (GPCR) internalization have been extensively studied, the functional characterization of constitutive internalization of these critically important receptors has received...
9.
Kasaragod V, Hausrat T, Schaefer N, Kuhn M, Christensen N, Tessmer I, et al.
Neuron
. 2019 Feb;
101(4):673-689.e11.
PMID: 30704910
The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAR)...
10.
Erlendsson S, Thorsen T, Vauquelin G, Ammendrup-Johnsen I, Wirth V, Martinez K, et al.
Elife
. 2019 Jan;
8.
PMID: 30605082
PDZ domain scaffold proteins are molecular modules orchestrating cellular signalling in space and time. Here, we investigate assembly of PDZ scaffolds using supported cell membrane sheets, a unique experimental setup...