Kenneth J Livak
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Explore the profile of Kenneth J Livak including associated specialties, affiliations and a list of published articles.
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21143
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Recent Articles
1.
Braun D, Moranzoni G, Chea V, McGregor B, Blass E, Tu C, et al.
Nature
. 2025 Feb;
639(8054):474-482.
PMID: 39910301
Personalized cancer vaccines (PCVs) can generate circulating immune responses against predicted neoantigens. However, whether such responses can target cancer driver mutations, lead to immune recognition of a patient's tumour and...
2.
Treon S, Kotton C, Park D, Moranzoni G, Lemvigh C, Gathe Jr J, et al.
Front Immunol
. 2025 Feb;
15:1369619.
PMID: 39906744
Background: Cytokine release triggered by a hyperactive immune response is thought to contribute to severe acute respiratory syndrome coronavirus 2019 (SARS-CoV-2)-related respiratory failure. Bruton tyrosine kinase (BTK) is involved in...
3.
Maurer K, Park C, Mani S, Borji M, Raths F, Gouin 3rd K, et al.
Sci Immunol
. 2025 Jan;
10(103):eadr0782.
PMID: 39854478
Understanding how intratumoral immune populations coordinate antitumor responses after therapy can guide treatment prioritization. We systematically analyzed an established immunotherapy, donor lymphocyte infusion (DLI), by assessing 348,905 single-cell transcriptomes from...
4.
Yeo Y, Chang Y, Qiu H, Yiu S, Michel H, Wu W, et al.
bioRxiv
. 2025 Jan;
PMID: 39764057
The advent of spatial transcriptomics and spatial proteomics have enabled profound insights into tissue organization to provide systems-level understanding of diseases. Both technologies currently remain largely independent, and emerging same...
5.
Maurer K, Grabski I, Houot R, Gohil S, Miura S, Redd R, et al.
Blood
. 2024 Sep;
144(24):2490-2502.
PMID: 39241199
Engineered cellular therapy with CD19-targeting chimeric antigen receptor T cells (CAR-Ts) has revolutionized outcomes for patients with relapsed/refractory large B-cell lymphoma (LBCL), but the cellular and molecular features associated with...
6.
Park C, Mani S, Beltran-Velez N, Maurer K, Huang T, Li S, et al.
Genome Res
. 2024 Sep;
34(9):1384-1396.
PMID: 39237300
Characterizing cell-cell communication and tracking its variability over time are crucial for understanding the coordination of biological processes mediating normal development, disease progression, and responses to perturbations such as therapies....
7.
Penter L, Cieri N, Maurer K, Kwok M, Lyu H, Lu W, et al.
Blood Cancer Discov
. 2024 Sep;
5(6):442-459.
PMID: 39236287
Combined tracking of clonal evolution and chimeric cell phenotypes could enable detection of the key cellular populations associated with response following therapy, including after allogeneic hematopoietic stem cell transplantation (HSCT)....
8.
Cieri N, Hookeri N, Stromhaug K, Li L, Keating J, Diaz-Fernandez P, et al.
Nat Biotechnol
. 2024 Aug;
PMID: 39169264
T cell alloreactivity against minor histocompatibility antigens (mHAgs)-polymorphic peptides resulting from donor-recipient (D-R) disparity at sites of genetic polymorphisms-is at the core of the therapeutic effect of allogeneic hematopoietic cell...
9.
Huang X, Lee S, Chen K, Kawaguchi R, Wiskow O, Ghosh S, et al.
Brain Commun
. 2024 Jun;
6(3):fcae202.
PMID: 38911266
While voltage-gated potassium channels have critical roles in controlling neuronal excitability, they also have non-ion-conducting functions. Kv8.1, encoded by the KCNV1 gene, is a 'silent' ion channel subunit whose biological...
10.
Walker M, Li S, Livak K, Karaa A, Wu C, Mootha V
J Inherit Metab Dis
. 2024 Mar;
47(4):757-765.
PMID: 38499449
T cells have been shown to maintain a lower percentage (heteroplasmy) of the pathogenic m.3243A>G variant (MT-TL1, associated with maternally inherited diabetes and deafness [MIDD] and mitochondrial encephalomyopathy with lactic...