Kenneth D Setchell
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Explore the profile of Kenneth D Setchell including associated specialties, affiliations and a list of published articles.
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7
Citations
324
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0
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Recent Articles
1.
Hegde S, Akbar H, Wellendorf A, Nestheide S, Johnson J, Zhao X, et al.
Blood
. 2024 Aug;
144(16):1732-1746.
PMID: 39088777
Patients with thrombocytopenia require platelet transfusion to prevent and stop hemorrhage. Cold storage of platelets results in complex molecular lesions, including changes in membrane microdomains that are recognized by host...
2.
Kamath B, Spino C, McLain R, Magee J, Fredericks E, Setchell K, et al.
Hepatol Commun
. 2020 Jul;
4(7):1012-1018.
PMID: 32626833
Pruritus is a debilitating symptom for patients with Alagille syndrome (ALGS). In a previously reported trial of maralixibat, an investigational antipruritic agent, itching was assessed using a digital diary based...
3.
Taylor V, Stone H, Schuh M, Zhao X, Setchell K, Erkan E
Kidney Int Rep
. 2019 Dec;
4(12):1763-1769.
PMID: 31844815
No abstract available.
4.
Shukla S, Milewski D, Pradhan A, Rama N, Rice K, Le T, et al.
Mol Cancer Ther
. 2019 May;
18(7):1217-1229.
PMID: 31040162
The oncogenic transcription factor FOXM1 has been previously shown to play a critical role in carcinogenesis by inducing cellular proliferation in multiple cancer types. A small-molecule compound, Robert Costa Memorial...
5.
Shneider B, Spino C, Kamath B, Magee J, Bass L, Setchell K, et al.
Hepatol Commun
. 2018 Oct;
2(10):1184-1198.
PMID: 30288474
Medically refractory, severe, cholestasis-induced pruritus in Alagille syndrome may be improved by surgical interruption of the enterohepatic circulation. This multicenter trial (NCT02057692) tested the hypothesis that the intestinal bile acid...
6.
Pandey M, Burrow T, Rani R, Martin L, Witte D, Setchell K, et al.
Nature
. 2017 Feb;
543(7643):108-112.
PMID: 28225753
Gaucher disease is caused by mutations in GBA1, which encodes the lysosomal enzyme glucocerebrosidase (GCase). GBA1 mutations drive extensive accumulation of glucosylceramide (GC) in multiple innate and adaptive immune cells...
7.
Kohli R, Bradley D, Setchell K, Eagon J, Abumrad N, Klein S
J Clin Endocrinol Metab
. 2013 Mar;
98(4):E708-12.
PMID: 23457410
Context: It has been hypothesized that increased plasma bile acids (BAs) contribute to metabolic improvements after Roux-en-Y gastric bypass (RYGB) surgery by the G protein-coupled receptor TGR5-mediated effects on glucagon-like...