Kenneth D Karlin
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Explore the profile of Kenneth D Karlin including associated specialties, affiliations and a list of published articles.
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189
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2934
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Recent Articles
1.
Braun A, Gee L, Waters M, Jose A, Baker M, Mara M, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(8):e2420205122.
PMID: 39982745
High-valent Fe=O species are common intermediates in biological and artificial catalysts. Heme and nonheme S=1 Fe=O sites have been synthesized and studied for decades but little quantitative experimental comparison of...
2.
Panda S, Adam S, Phan H, Rogler P, Hota P, Helms J, et al.
Chem Sci
. 2025 Jan;
16(5):2402-2412.
PMID: 39790985
In biological systems, heme-copper oxidase (HCO) enzymes play a crucial role in the oxygen reduction reaction (ORR), where the pivotal O-O bond cleavage of the (heme)Fe-peroxo-Cu intermediate is facilitated by...
3.
Karlin K, Hota P, Kim B, Panda S, Phan H
Bull Jpn Soc Coord Chem
. 2024 Oct;
83:16-27.
PMID: 39372915
Synthetic copper-dioxygen complex design, generation and characterization, play a crucial role in elucidating the structure/function of copper-based metalloenzymes, including dopamine -monooxygenase, lytic polysaccharide monooxygenases, methane monooxygenase, tyrosinase, hemocyanin, and catechol...
4.
Hota P, Panda S, Phan H, Kim B, Siegler M, Karlin K
J Am Chem Soc
. 2024 Aug;
146(34):23854-23871.
PMID: 39141923
The chemistry of copper-dioxygen complexes is relevant to copper enzymes in biology as well as in (ligand)Cu-O (or Cu-O) species utilized in oxidative transformations. For overall energy considerations, as applicable...
5.
Panda S, Phan H, Dunietz E, Brueggemeyer M, Hota P, Siegler M, et al.
J Am Chem Soc
. 2024 May;
146(22):14942-14947.
PMID: 38775712
Synthetic side-on peroxide-bound dicopper(II) () complexes are important for understanding the active site structure/function of many copper-containing enzymes. This work highlights the formation of new {Cu(μ-η:η-O)Cu} complexes (with electronic absorption...
6.
Hota P, Jose A, Panda S, Dunietz E, Herzog A, Wojcik L, et al.
J Am Chem Soc
. 2024 Apr;
146(19):13066-13082.
PMID: 38688016
Copper ion is a versatile and ubiquitous facilitator of redox chemical and biochemical processes. These include the binding of molecular oxygen to copper(I) complexes where it undergoes stepwise reduction-protonation. A...
7.
Panda S, Phan H, Karlin K
J Inorg Biochem
. 2023 Sep;
249:112367.
PMID: 37742491
Cytochrome c oxidase (CcO), also widely known as mitochondrial electron-transport-chain complex IV, is a multi-subunit transmembrane protein responsible for catalyzing the last step of the electron transport chain, dioxygen reduction...
8.
Kim B, Karlin K
Acc Chem Res
. 2023 Aug;
56(16):2197-2212.
PMID: 37527056
In this Account, we overview and highlight synthetic bioinorganic chemistry focused on initial adducts formed from the reaction of reduced ligand-copper(I) coordination complexes with molecular oxygen, reactions that produce ligand-Cu(O)...
9.
Kim B, Brueggemeyer M, Transue W, Park Y, Cho J, Siegler M, et al.
J Am Chem Soc
. 2023 May;
145(21):11735-11744.
PMID: 37195014
Lytic polysaccharide monooxygenases have received significant attention as catalytic convertors of biomass to biofuel. Recent studies suggest that its peroxygenase activity (i.e., using HO as an oxidant) is more important...
10.
Bhadra M, Albert T, Franke A, Josef V, Ivanovic-Burmazovic I, Swart M, et al.
J Am Chem Soc
. 2023 Jan;
145(4):2230-2242.
PMID: 36652374
Transition-metal-mediated reductive coupling of nitric oxide (NO) to nitrous oxide (NO) has significance across the fields of industrial chemistry, biochemistry, medicine, and environmental health. Herein, we elucidate a density functional...