Kenichiro Nagahama
Overview
Explore the profile of Kenichiro Nagahama including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
137
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Recent Articles
1.
Nagahama K, Jung V, Kwon H
Curr Opin Neurobiol
. 2025 Mar;
92:102997.
PMID: 40056794
Decoding the neural substrates that underlie learning and behavior is a fundamental goal in neuroscience. Identifying "key players" at the molecular, cellular, and circuit levels has become possible with recent...
2.
Son S, Nagahama K, Lee J, Jung K, Kwak C, Kim J, et al.
Nat Methods
. 2024 Jan;
21(2):353-360.
PMID: 38191933
The structural plasticity of synapses is crucial for regulating brain functions. However, currently available methods for studying synapse organization based on split fluorescent proteins (FPs) have been limited in assessing...
3.
Obi-Nagata K, Suzuki N, Miyake R, MacDonald M, Fish K, Ozawa K, et al.
Sci Adv
. 2023 Jun;
9(23):eade5973.
PMID: 37294752
Human genetics strongly support the involvement of synaptopathy in psychiatric disorders. However, trans-scale causality linking synapse pathology to behavioral changes is lacking. To address this question, we examined the effects...
4.
Hyun J, Nagahama K, Namkung H, Mignocchi N, Roh S, Hannan P, et al.
Nat Commun
. 2022 Dec;
13(1):7692.
PMID: 36509775
Verifying causal effects of neural circuits is essential for proving a direct circuit-behavior relationship. However, techniques for tagging only active neurons with high spatiotemporal precision remain at the beginning stages....
5.
Toriumi K, Berto S, Koike S, Usui N, Dan T, Suzuki K, et al.
Redox Biol
. 2021 Jul;
45:102057.
PMID: 34198071
Methylglyoxal (MG) is a reactive and cytotoxic α-dicarbonyl byproduct of glycolysis. Our bodies have several bio-defense systems to detoxify MG, including an enzymatic system by glyoxalase (GLO) 1 and GLO2....
6.
Nagahama K, Fujino S, Watanabe T, Uesaka N, Kano M
STAR Protoc
. 2021 May;
2(2):100469.
PMID: 33937875
Here, we present a comprehensive protocol to analyze the roles of disease-related genes in synaptic transmission. We have developed a pipeline of electrophysiological techniques and combined these with optogenetics in...
7.
Sacai H, Sakoori K, Konno K, Nagahama K, Suzuki H, Watanabe T, et al.
Nat Commun
. 2020 Oct;
11(1):5140.
PMID: 33046712
Autism spectrum disorder (ASD) is thought to result from deviation from normal development of neural circuits and synaptic function. Many genes with mutation in ASD patients have been identified. Here...
8.
Nagahama K, Sakoori K, Watanabe T, Kishi Y, Kawaji K, Koebis M, et al.
Cell Rep
. 2020 Sep;
32(11):108126.
PMID: 32937141
SETD1A encodes a histone methyltransferase whose de novo mutations are identified in schizophrenia (SCZ) patients and confer a large increase in disease risk. Here, we generate Setd1a mutant mice carrying...
9.
Saito R, Koebis M, Nagai T, Shimizu K, Liao J, Wulaer B, et al.
Transl Psychiatry
. 2020 Feb;
10(1):35.
PMID: 32066675
The 22q11.2 deletion syndrome (22q11.2DS) is associated with an increased risk for psychiatric disorders. Although most of the 22q11.2DS patients have a 3.0-Mb deletion, existing mouse models only mimic a...