Kelvin C M Lee
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Explore the profile of Kelvin C M Lee including associated specialties, affiliations and a list of published articles.
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13
Citations
151
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Recent Articles
1.
Lee K, Chung B, Siu D, Ho S, Ng D, Tsia K
Lab Chip
. 2024 Aug;
24(17):4182-4197.
PMID: 39101363
Inertial focusing excels at the precise spatial ordering and separation of microparticles by size within fluid flows. However, this advantage, resulting from its inherent size-dependent dispersion, could turn into a...
2.
Lo M, Siu D, Lee K, Wong J, Yeung M, Hsin M, et al.
Adv Sci (Weinh)
. 2024 Jun;
11(29):e2307591.
PMID: 38864546
Image-based cytometry faces challenges due to technical variations arising from different experimental batches and conditions, such as differences in instrument configurations or image acquisition protocols, impeding genuine biological interpretation of...
3.
Zhang Z, Lee K, Siu D, Lo M, Lai Q, Lam E, et al.
Commun Biol
. 2023 Apr;
6(1):449.
PMID: 37095203
Complex and irregular cell architecture is known to statistically exhibit fractal geometry, i.e., a pattern resembles a smaller part of itself. Although fractal variations in cells are proven to be...
4.
Siu D, Lee K, Chung B, Wong J, Zheng G, Tsia K
Lab Chip
. 2023 Jan;
23(5):1011-1033.
PMID: 36601812
Propelled by the striking advances in optical microscopy and deep learning (DL), the role of imaging in lab-on-a-chip has dramatically been transformed from a silo inspection tool to a quantitative...
5.
Lai Q, Yip G, Wu J, Wong J, Lo M, Lee K, et al.
Nat Protoc
. 2021 Aug;
16(9):4227-4264.
PMID: 34341580
Laser scanning is used in advanced biological microscopy to deliver superior imaging contrast, resolution and sensitivity. However, it is challenging to scale up the scanning speed required for interrogating a...
6.
Lee K, Guck J, Goda K, Tsia K
Trends Biotechnol
. 2021 Apr;
39(12):1249-1262.
PMID: 33895013
The biophysical properties of cells reflect their identities, underpin their homeostatic state in health, and define the pathogenesis of disease. Recent leapfrogging advances in biophysical cytometry now give access to...
7.
Wang M, Lee K, Chung B, Bogaraju S, Ng H, Wong J, et al.
IEEE Trans Neural Netw Learn Syst
. 2021 Jan;
33(7):2853-2866.
PMID: 33434136
Real-time in situ image analytics impose stringent latency requirements on intelligent neural network inference operations. While conventional software-based implementations on the graphic processing unit (GPU)-accelerated platforms are flexible and have...
8.
Siu D, Lee K, Lo M, Stassen S, Wang M, Zhang I, et al.
Lab Chip
. 2020 Sep;
20(20):3696-3708.
PMID: 32935707
The association of the intrinsic optical and biophysical properties of cells to homeostasis and pathogenesis has long been acknowledged. Defining these label-free cellular features obviates the need for costly and...
9.
Stassen S, Siu D, Lee K, Ho J, So H, Tsia K
Bioinformatics
. 2020 Jan;
36(9):2778-2786.
PMID: 31971583
Motivation: New single-cell technologies continue to fuel the explosive growth in the scale of heterogeneous single-cell data. However, existing computational methods are inadequately scalable to large datasets and therefore cannot...
10.
Lee K, Wang M, Cheah K, Chan G, So H, Wong K, et al.
Cytometry A
. 2019 Apr;
95(5):510-520.
PMID: 31012276
Cellular biophysical properties are the effective label-free phenotypes indicative of differences in cell types, states, and functions. However, current biophysical phenotyping methods largely lack the throughput and specificity required in...