Kelly J Chandler
Overview
Explore the profile of Kelly J Chandler including associated specialties, affiliations and a list of published articles.
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11
Citations
468
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Recent Articles
1.
Mortlock D, Fang Z, Chandler K, Hou Y, Bickford L, de Bock C, et al.
Genes (Basel)
. 2022 Jul;
13(7).
PMID: 35885978
The human capacity to speak is fundamental to our advanced intellectual, technological and social development. Yet so very little is known regarding the evolutionary genetics of speech or its relationship...
2.
Boyles A, Beverly B, Fenton S, Jackson C, Jukic A, Sutherland V, et al.
J Womens Health (Larchmt)
. 2020 Nov;
30(2):245-252.
PMID: 33211615
Nongenetic, environmental factors contribute to maternal morbidity and mortality through chemical exposures via air, water, soil, food, and consumer products. Pregnancy represents a particularly sensitive window of susceptibility during which...
3.
Ainoya K, Moriguchi T, Ohmori S, Souma T, Takai J, Morita M, et al.
Mol Cell Biol
. 2012 Apr;
32(12):2312-22.
PMID: 22493062
During renal development, the proper emergence of the ureteric bud (UB) from the Wolffian duct is essential for formation of the urinary system. Previously, we showed that expression of transcription...
4.
Sipes N, Martin M, Reif D, Kleinstreuer N, Judson R, Singh A, et al.
Toxicol Sci
. 2011 Aug;
124(1):109-27.
PMID: 21873373
Environmental Protection Agency's ToxCast project is profiling the in vitro bioactivity of chemicals to assess pathway-level and cell-based signatures that correlate with observed in vivo toxicity. We hypothesized that developmental...
5.
Kleinstreuer N, Judson R, Reif D, Sipes N, Singh A, Chandler K, et al.
Environ Health Perspect
. 2011 Jul;
119(11):1596-603.
PMID: 21788198
Background: Understanding health risks to embryonic development from exposure to environmental chemicals is a significant challenge given the diverse chemical landscape and paucity of data for most of these compounds....
6.
Chandler K, Barrier M, Jeffay S, Nichols H, Kleinstreuer N, Singh A, et al.
PLoS One
. 2011 Jun;
6(6):e18540.
PMID: 21666745
The vast landscape of environmental chemicals has motivated the need for alternative methods to traditional whole-animal bioassays in toxicity testing. Embryonic stem (ES) cells provide an in vitro model of...
7.
Barrier M, Jeffay S, Nichols H, Chandler K, Hoopes M, Slentz-Kesler K, et al.
Reprod Toxicol
. 2011 Feb;
31(4):383-91.
PMID: 21296659
An adherent cell differentiation and cytotoxicity (ACDC) assay was developed using pluripotent J1 mouse embryonic stem cells (mESCs). Adherent mESCs were used to evaluate chemical-induced effects on both stem cell...
8.
Chandler K, Chandler R, Mortlock D
Dev Biol
. 2009 Jan;
327(2):590-602.
PMID: 19159624
Bone morphogenetic protein 4 (Bmp4) is a multi-functional, developmentally regulated gene that is essential for mouse development, as most Bmp4-null mouse embryos die at the onset of gastrulation and fail...
9.
Boyle S, Misfeldt A, Chandler K, Deal K, Southard-Smith E, Mortlock D, et al.
Dev Biol
. 2007 Dec;
313(1):234-45.
PMID: 18061157
Classic tissue recombination and in vitro lineage tracing studies suggest that condensed metanephric mesenchyme (MM) gives rise to nephronic epithelium of the adult kidney. However, these studies do not distinguish...
10.
Chandler K, Chandler R, Broeckelmann E, Hou Y, Southard-Smith E, Mortlock D
Mamm Genome
. 2007 Sep;
18(10):693-708.
PMID: 17882484
Bacterial artificial chromosomes (BACs) are excellent tools for manipulating large DNA fragments and, as a result, are increasingly utilized to engineer transgenic mice by pronuclear injection. The demand for BAC...