Kelli Jones
Overview
Explore the profile of Kelli Jones including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
84
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Recent Articles
1.
Raina K, Forbes C, Stronk R, Rappi Jr J, Eastman K, Zaware N, et al.
Cell Chem Biol
. 2024 Aug;
31(8):1490-1502.e42.
PMID: 39116881
We describe a protein proximity inducing therapeutic modality called Regulated Induced Proximity Targeting Chimeras or RIPTACs: heterobifunctional small molecules that elicit a stable ternary complex between a target protein (TP)...
2.
Raina K, Forbes C, Stronk R, Rappi Jr J, Eastman K, Gerritz S, et al.
bioRxiv
. 2023 Jan;
PMID: 36711980
While specific cell signaling pathway inhibitors have yielded great success in oncology, directly triggering cancer cell death is one of the great drug discovery challenges facing biomedical research in the...
3.
Gayle S, Paradis T, Jones K, Vasquez J, Paralkar V
Immunotherapy
. 2023 Jan;
14(18):1467-1480.
PMID: 36597724
To determine whether antigen-independent targeting of the TOP1 inhibitor exatecan to tumor with a pH-sensitive peptide (CBX-12) produces superior synergy with immunotherapy compared with unconjugated exatecan. and functional assays were...
4.
Easton A, Jensen M, Wang C, Hagedorn P, Li Y, Weed M, et al.
Mol Ther Nucleic Acids
. 2022 Sep;
29:625-642.
PMID: 36090761
Tau is a microtubule-associated protein (, tau) implicated in the pathogenesis of tauopathies, a spectrum of neurodegenerative disorders characterized by accumulation of hyperphosphorylated, aggregated tau. Because tau pathology can be...
5.
Jo U, Murai Y, Agama K, Sun Y, Saha L, Yang X, et al.
Mol Cancer Ther
. 2022 Apr;
21(7):1090-1102.
PMID: 35439320
Exatecan and deruxtecan are antineoplastic camptothecin derivatives in development as tumor-targeted-delivery warheads in various formulations including peptides, liposomes, polyethylene glycol nanoparticles, and antibody-drug conjugates. Here, we report the molecular pharmacology...
6.
Gallardo R, da Silva A, Gilbert R, Alfonso M, Conley A, Jones K, et al.
Avian Dis
. 2022 Feb;
66(1):112-118.
PMID: 35191651
Infectious bronchitis is a respiratory disease of chickens caused by a gammacoronavirus named infectious bronchitis virus (IBV). In addition to affecting the respiratory tract, IBV may also induce urogenital infections,...
7.
Hagedorn P, Brown J, Easton A, Pierdomenico M, Jones K, Olson R, et al.
Nucleic Acid Ther
. 2022 Feb;
32(3):151-162.
PMID: 35166597
Antisense oligonucleotides are a relatively new therapeutic modality and safety evaluation is still a developing area of research. We have observed that some oligonucleotides can produce acute, nonhybridization dependent, neurobehavioral...
8.
Gayle S, Aiello R, Leelatian N, Beckta J, Bechtold J, Bourassa P, et al.
NAR Cancer
. 2021 Dec;
3(4):zcab047.
PMID: 34888524
[This corrects the article DOI: 10.1093/narcan/zcab021.].
9.
Gayle S, Aiello R, Leelatian N, Beckta J, Bechtold J, Bourassa P, et al.
NAR Cancer
. 2021 Jul;
3(2):zcab021.
PMID: 34316708
Topoisomerase inhibitors are potent DNA damaging agents which are widely used in oncology, and they demonstrate robust synergistic tumor cell killing in combination with DNA repair inhibitors, including poly(ADP)-ribose polymerase...
10.
Cook J, Zusi F, Mcdonald I, King D, Hill M, Iwuagwu C, et al.
J Med Chem
. 2016 Dec;
59(24):11171-11181.
PMID: 27958732
The design and synthesis of a series of quinuclidine-containing spirooxazolidines ("spiroimidates") and their utility as α7 nicotinic acetylcholine receptor partial agonists are described. Selected members of the series demonstrated excellent...