Keith A Webster
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Explore the profile of Keith A Webster including associated specialties, affiliations and a list of published articles.
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101
Citations
2028
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Recent Articles
1.
Huang C, Kaur A, Ji L, Tian H, Webster K, Li W
Gene Ther
. 2024 Sep;
31(11-12):587-593.
PMID: 39333408
Efforts to develop gene therapy for long-term treatment of neovascular disease are hampered by ongoing concerns that biologics against vascular endothelial growth factor (VEGF) inhibit both physiological and pathological angiogenesis...
2.
Huang C, Waduge P, Kaur A, Tian H, Weng C, Stout J, et al.
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273454
Secretogranin III (Scg3) is a diabetic retinopathy (DR)-restricted angiogenic factor identified in preclinical studies as a target for DR therapy. Previously, our group generated and characterized ML49.3, an anti-Scg3 monoclonal...
3.
Fu Y, Zhang Z, Webster K, Paulus Y
Biomolecules
. 2024 Mar;
14(3).
PMID: 38540673
Despite extensive use of intravitreal anti-vascular endothelial growth factor (anti-VEGF) biologics for over a decade, neovascular age-related macular degeneration (nAMD) or choroidal neovascularization (CNV) continues to be a major cause...
4.
Webster K
Genes (Basel)
. 2024 Jan;
15(1).
PMID: 38275616
Approximately 6% of adults worldwide suffer from peripheral artery disease (PAD), primarily caused by atherosclerosis of lower limb arteries. Despite optimal medical care and revascularization, many PAD patients remain symptomatic...
5.
Lalwani R, Volmar C, Wahlestedt C, Webster K, Shehadeh L
Biomedicines
. 2023 Dec;
11(12).
PMID: 38137453
Alzheimer's disease (AD) is characterized by progressive accumulations of extracellular amyloid-beta (Aβ) aggregates from soluble oligomers to insoluble plaques and hyperphosphorylated intraneuronal tau, also from soluble oligomers to insoluble neurofibrillary...
6.
Condor Capcha J, Kamiar A, Robleto E, Saad A, Cui T, Wong A, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(48):e2308342120.
PMID: 37983492
COVID-19 pneumonia causes acute lung injury and acute respiratory distress syndrome (ALI/ARDS) characterized by early pulmonary endothelial and epithelial injuries with altered pulmonary diffusing capacity and obstructive or restrictive physiology....
7.
Kamiar A, Alitter Q, Capcha J, Saad A, Webster K, Shehadeh L
BMC Nephrol
. 2023 Oct;
24(1):300.
PMID: 37828432
Background: Alport syndrome (AS) is caused by mutations in type IV collagen genes that typically target and compromise the integrity of basement membranes in kidney, ocular, and sensorineural cochlear tissues....
8.
Huang C, Ji L, Kaur A, Tian H, Waduge P, Webster K, et al.
Biomedicines
. 2023 Jul;
11(7).
PMID: 37509549
Neovascular age-related macular degeneration (nAMD) with choroidal neovascularization (CNV) is a leading cause of blindness in the elderly in developed countries. The disease is currently treated with anti-angiogenic biologics, including...
9.
Ji L, Waduge P, Wu Y, Huang C, Kaur A, Oliveira P, et al.
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37445707
Diabetic retinopathy (DR), a leading cause of vision loss in working-age adults, induces mosaic patterns of vasculopathy that may be associated with spatial heterogeneity of intraretinal endothelial cells. We recently...
10.
Aguilar-Caballero D, Capcha J, Caballero V, Young K, Duara S, Borchetta M, et al.
Front Pediatr
. 2023 Jun;
11:1144230.
PMID: 37287630
Vertical transmission of SARS-CoV-2 from mother to fetus is widely accepted. Whereas most infected neonates present with mild symptoms or are asymptomatic, respiratory distress syndrome (RDS) and abnormal lung images...