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Keisuke Osaki

Explore the profile of Keisuke Osaki including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 10
Citations 69
Followers 0
Related Specialties
Nephrology
General Medicine
Science
Top 10 Co-Authors
Keita P Mori
Motoko Yanagita
Akira Ishii
Hideki Yokoi
Naohiro Toda
Shoko Ohno
Yukiko Kato
Masato Kasahara
Kiyoshi Mori
Kenichi Koga
Published In
Intern Med
Sci Rep
Clin Exp Nephrol
Kidney Int
Int J Hematol
Affiliations
Soon will be listed here.
Recent Articles
1.
Steroid-resistant nephrotic syndrome due to renal-limited thrombotic microangiopathy and membranous nephropathy after allogeneic hematopoietic stem cell transplantation successfully treated with calcineurin inhibitors
Okada S, Nishikubo M, Shimomura Y, Hiramoto N, Osaki K, Hara S, et al.
Int J Hematol . 2025 Jan; PMID: 39881108
Transplantation-associated thrombotic microangiopathy (TMA) is a severe complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with high mortality. As calcineurin inhibitors (CNIs) reportedly contribute to TMA via drug-induced endothelial injury,...
2.
Prospective randomized trial of antibiotic prophylaxis for percutaneous renal biopsy
Yahata K, Koga K, Hirai D, Seta K, Mori K, Higashi Y, et al.
Clin Exp Nephrol . 2024 Nov; 29(3):269-275. PMID: 39565468
Background: Infection is a rare complication of percutaneous renal biopsy (RB). However, the questionnaire included in the Kidney Biopsy Guidebook 2020 in Japan revealed that antibiotic prophylaxis (AP) was administered...
3.
Matrix metalloproteinase-10 deficiency has protective effects against peritoneal inflammation and fibrosis via transcription factor NFκΒ pathway inhibition
Ishimura T, Ishii A, Yamada H, Osaki K, Toda N, Mori K, et al.
Kidney Int . 2023 Aug; 104(5):929-942. PMID: 37652204
One of the most common causes of discontinued peritoneal dialysis is impaired peritoneal function. However, its molecular mechanisms remain unclear. Previously, by microarray analysis of mouse peritoneum, we showed that...
4.
Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi
Sugioka S, Yamada H, Ishii A, Kato Y, Yamada R, Mori K, et al.
Kidney Int . 2023 Jun; 104(3):508-525. PMID: 37356621
Natriuretic peptides exert not only blood-lowering but also kidney-protective effects through guanylyl cyclase-A (GC-A), a natriuretic peptide receptor. Signaling through GC-A has been shown to protect podocytes from aldosterone-induced glomerular...
5.
Deletion of connective tissue growth factor ameliorates peritoneal fibrosis by inhibiting angiogenesis and inflammation
Toda N, Mori K, Kasahara M, Koga K, Ishii A, Mori K, et al.
Nephrol Dial Transplant . 2017 Nov; 33(6):943-953. PMID: 29165602
Background: Connective tissue growth factor (CTGF/CCN2) regulates the signalling of other growth factors and promotes fibrosis. CTGF is increased in mice and humans with peritoneal fibrosis. Inhibition of CTGF has...
6.
Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition
Kato Y, Mori K, Kasahara M, Osaki K, Ishii A, Mori K, et al.
Sci Rep . 2017 Apr; 7:46624. PMID: 28429785
Guanylyl cyclase-A (GC-A) signaling, a natriuretic peptide receptor, exerts renoprotective effects by stimulating natriuresis and reducing blood pressure. Previously we demonstrated massive albuminuria with hypertension in uninephrectomized, aldosterone-infused, and high...
7.
Crucial Role of Mesangial Cell-derived Connective Tissue Growth Factor in a Mouse Model of Anti-Glomerular Basement Membrane Glomerulonephritis
Toda N, Mori K, Kasahara M, Ishii A, Koga K, Ohno S, et al.
Sci Rep . 2017 Feb; 7:42114. PMID: 28191821
Connective tissue growth factor (CTGF) coordinates the signaling of growth factors and promotes fibrosis. Neonatal death of systemic CTGF knockout (KO) mice has hampered analysis of CTGF in adult renal...
8.
Nephrotic range proteinuria as a strong risk factor for rapid renal function decline during pre-dialysis phase in type 2 diabetic patients with severely impaired renal function
Kitai Y, Doi Y, Osaki K, Sugioka S, Koshikawa M, Sugawara A
Clin Exp Nephrol . 2015 Feb; 19(6):1037-43. PMID: 25680889
Background: Proteinuria is an established risk factor for progression of renal disease, including diabetic nephropathy. The predictive power of proteinuria, especially nephrotic range proteinuria, for progressive renal deterioration has been...
9.
Systemic mycobacteriosis in an aborted thoroughbred fetus in Japan
Sano Y, Matsuda K, Osaki K, Miyasho T, Tsuda T, Taniyama H
J Vet Med Sci . 2015 Feb; 76(12):1617-21. PMID: 25649944
A male Thoroughbred fetus was aborted on day 251 of pregnancy. Gross and histological examinations detected systemic granulomatous lesions in many superficial and visceral lymph nodes and organs including the...
10.
Distal renal tubular acidosis that became exacerbated by proton pump inhibitor use
Okamoto N, Nambu T, Matsuda Y, Matsuo K, Osaki K, Kanai Y, et al.
Intern Med . 2012 Sep; 51(18):2591-5. PMID: 22989832
Acid-base imbalances and electrolyte disorders induced by proton pump inhibitors (PPIs) are extremely rare. However, under certain conditions, PPIs may cause metabolic acidosis or hypokalemia, probably due to an inhibitory...