Kei Watari
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Explore the profile of Kei Watari including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
95
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Recent Articles
1.
Ogata Y, Sato T, Kato K, Kikuchi K, Mitsuhashi K, Watari K, et al.
Int J Infect Dis
. 2024 Apr;
143:107038.
PMID: 38580070
A 76-year-old woman infected with Yezo virus (YEZV) developed liver dysfunction and thrombocytopenia following a tick bite. Despite the severity of her elevated liver enzymes and reduced platelet counts, the...
2.
Okagawa T, Konnai S, Goto S, Sajiki Y, Ganbaatar O, Watari K, et al.
Vet Res
. 2023 Sep;
54(1):82.
PMID: 37759311
Immune checkpoint molecules PD-1/PD-L1 cause T-cell exhaustion and contribute to disease progression in chronic infections of cattle. We established monoclonal antibodies (mAbs) that specifically inhibit the binding of bovine PD-1/PD-L1;...
3.
Okagawa T, Konnai S, Nakamura H, Ganbaatar O, Sajiki Y, Watari K, et al.
Vaccines (Basel)
. 2023 Mar;
11(3).
PMID: 36992143
Interactions between programmed death 1 (PD-1) and PD-ligand 1 (PD-L1) cause functional exhaustion of T cells by inducing inhibitory signals, thereby attenuating effector functions of T cells. We have developed...
4.
Nakamura H, Konnai S, Okagawa T, Maekawa N, Sajiki Y, Watari K, et al.
J Virol
. 2023 Jan;
97(1):e0143022.
PMID: 36598199
Bovine leukemia virus (BLV) is a retrovirus that causes enzootic bovine leukosis (EBL) in cattle and is widespread in many countries, including Japan. Recent studies have revealed that the expression...
5.
Sajiki Y, Konnai S, Watari K, Okagawa T, Tanaka A, Kawaji S, et al.
Infect Immun
. 2022 Sep;
90(10):e0021022.
PMID: 36102658
Paratuberculosis is a chronic enteritis of ruminants caused by the facultative intracellular pathogen Mycobacterium avium subsp. . The Th1 response inhibits the proliferation of M. avium subsp. during the early...
6.
Maekawa N, Konnai S, Asano Y, Sajiki Y, Deguchi T, Okagawa T, et al.
Sci Rep
. 2022 Jun;
12(1):9265.
PMID: 35665759
Immune checkpoint inhibitors (ICIs) such as anti-PD-L1 antibodies are widely used to treat human cancers, and growing evidence suggests that ICIs are promising treatments for canine malignancies. However, only some...
7.
Watari K, Konnai S, Okagawa T, Maekawa N, Sajiki Y, Kato Y, et al.
J Vet Med Sci
. 2021 Nov;
84(1):6-15.
PMID: 34789592
Our previous studies demonstrate the therapeutic efficacy against bovine diseases of an anti-bovine programmed death-ligand 1 (PD-L1) chimeric antibody. In humans, PD-1 and PD-L1 antibodies are more effective when combined...
8.
Kayasaki F, Okagawa T, Konnai S, Kohara J, Sajiki Y, Watari K, et al.
Vet Microbiol
. 2021 Jan;
254:108976.
PMID: 33453627
Diarrhea is a major cause of death in calves and this is linked directly to economic loss in the cattle industry. Fermented milk replacer (FMR) has been used widely in...
9.
Sajiki Y, Konnai S, Ikenaka Y, Gulay K, Kobayashi A, Parizi L, et al.
Sci Rep
. 2021 Jan;
11(1):1063.
PMID: 33441793
The tick Rhipicephalus microplus is a harmful parasite of cattle that causes considerable economic losses to the cattle breeding industry. Although R. microplus saliva (Rm-saliva) contains several immunosuppressants, any association...
10.
Goto S, Konnai S, Hirano Y, Kohara J, Okagawa T, Maekawa N, et al.
Front Vet Sci
. 2020 Mar;
7:12.
PMID: 32154274
Bovine mycoplasmosis caused by results in pneumonia and mastitis in cattle. We previously demonstrated that the programmed death 1 (PD-1)/PD-ligand 1 (PD-L1) pathway is involved in immune dysfunction during infection...