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Keh Sung Tsai

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Articles 17
Citations 410
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Recent Articles
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Chen P, Shih S, Wang P, Lin Y, Chu C, Lin J, et al.
Nat Commun . 2015 Jul; 6:7633. PMID: 26151496
Graves' disease is the leading cause of hyperthyroidism affecting 1.0-1.6% of the population. Antithyroid drugs are the treatment cornerstone, but may cause life-threatening agranulocytosis. Here we conduct a two-stage association...
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Chen B, Sheu M, Tsai K, Lan K, Guan S, Wu C, et al.
Antioxid Redox Signal . 2014 Sep; 23(15):1233-45. PMID: 25178318
Aims: Renal ischemia-reperfusion (I/R) is a major cause of acute renal failure. The mechanisms of I/R injury include endoplasmic reticulum (ER) stress, inflammatory responses, hypoxia, and generation of reactive oxygen...
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Chen Y, Tsai K, Chan D, Lan K, Chen C, Yang R, et al.
J Orthop Res . 2013 Dec; 32(4):573-80. PMID: 24375705
Proinflammatory cytokine interleukin-1β (IL-1β) stimulates several mediators of cartilage degradation and plays an important role in the pathogenesis of osteoarthritis (OA). Honokiol, a low molecular weight natural product isolated from...
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Chen Y, Sheu M, Tsai K, Yang R, Liu S
PLoS One . 2013 Jun; 8(6):e66611. PMID: 23776688
Accumulation of advanced glycation end products (AGEs) in joints is important in the development of cartilage destruction and damage in age-related osteoarthritis (OA). The aim of this study was to...
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Chen Y, Tsai K, Chiu C, Yang T, Lin T, Fu W, et al.
J Orthop Res . 2013 Mar; 31(7):1032-8. PMID: 23483610
Osteoarthritis (OA) is a degenerative joint disease involving a combination of cartilage degradation and inflammation. EGb761, a standardized extract of Ginkgo biloba leaves, holds an anti-inflammatory potency. Here, we determined...
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Huang C, Chen Y, Yang C, Tsai K, Yang R, Liu S
Kaohsiung J Med Sci . 2011 Sep; 27(9):402-10. PMID: 21914528
Arsenic is a naturally occurring toxic metalloid of global concern. Many studies have indicated a dose-response relationship between accumulative arsenic exposure and the prevalence of diabetes mellitus (DM) in arseniasis-endemic...
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Wu C, Sheu M, Tsai K, Chiang C, Liu S
Free Radic Biol Med . 2011 May; 51(3):671-80. PMID: 21616140
Although cisplatin attacks various tumors with remarkable efficacy, its clinical usage has been limited by its side effects, particularly nephrotoxicity. Salubrinal, a selective eukaryotic translation initiation factor 2 subunit α...
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Chen Y, Huang C, Yang C, Yen C, Tsai K, Liu S
Toxicol Appl Pharmacol . 2009 Dec; 243(3):323-31. PMID: 20006636
Mercury is a well-known highly toxic metal. In this study, we characterize and investigate the cytotoxicity and its possible mechanisms of inorganic mercury in pancreatic beta-cells. Mercury chloride (HgCl2) dose-dependently...
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Leu Y, Chen Y, Yang C, Huang C, Lin G, Tsai K, et al.
J Ethnopharmacol . 2009 May; 123(2):208-12. PMID: 19429364
Ethnopharmacological Relevance: Angelica genus (Umbelliferae) has traditionally been used as the medicine and health food considered alleviating several disorders including diabetes mellitus. Angelica hirsutiflora Liu Chao & Chuang is an...