Kazuyuki Fujihara
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Explore the profile of Kazuyuki Fujihara including associated specialties, affiliations and a list of published articles.
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21
Citations
207
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Recent Articles
1.
Liu D, Fujihara K, Yanagawa Y, Mushiake H, Ohshiro T
Front Neurol
. 2023 Oct;
14:1243301.
PMID: 37830095
Objective: To elucidate the functional role of gamma-aminobutyric acid (GABA)-ergic inhibition in suppressing epileptic brain activities such as spike-wave discharge (SWD), we recorded electroencephalogram (EEG) in knockout rats for (),...
2.
Fujihara K
Front Cell Neurosci
. 2023 May;
17:1161608.
PMID: 37168420
Abnormalities in the γ-aminobutyric acid (GABA) system have been reported in the postmortem brains of individuals with schizophrenia. In particular, the reduction of one of the GABA-synthesizing enzymes, the 67-kDa...
3.
Komiyama K, Iijima K, Kawabata-Iwakawa R, Fujihara K, Kakizaki T, Yanagawa Y, et al.
Sci Rep
. 2022 Apr;
12(1):6805.
PMID: 35474103
Patients with glioma often demonstrate epilepsy. We previously found burst discharges in the peritumoral area in patients with malignant brain tumors during biopsy. Therefore, we hypothesized that the peritumoral area...
4.
Tagawa M, Takei Y, Kato Y, Suto T, Hironaga N, Ohki T, et al.
Psychiatry Clin Neurosci
. 2022 Apr;
76(7):309-320.
PMID: 35397141
Aims: Schizophrenia (SZ) is characterized by psychotic symptoms and cognitive impairment, and is hypothesized to be a 'dysconnection' syndrome due to abnormal neural network formation. Although numerous studies have helped...
5.
Jiang W, Kakizaki T, Fujihara K, Miyata S, Zhang Y, Suto T, et al.
FASEB J
. 2021 Dec;
36(2):e22123.
PMID: 34972242
GABA is a major neurotransmitter in the mammalian central nervous system. Glutamate decarboxylase (GAD) synthesizes GABA from glutamate, and two isoforms of GAD, GAD65, and GAD67, are separately encoded by...
6.
Fujihara K, Sato T, Higeta K, Miyasaka Y, Mashimo T, Yanagawa Y
Front Pharmacol
. 2021 Apr;
12:646088.
PMID: 33859565
Glutamate decarboxylase 67-kDa isoform (GAD67), which is encoded by the gene, is one of the key enzymes that produce GABA. The reduced expression of GAD67 has been linked to the...
7.
Miyata S, Kakizaki T, Fujihara K, Obinata H, Hirano T, Nakai J, et al.
Mol Brain
. 2021 Jan;
14(1):5.
PMID: 33413507
Reduced expression of glutamate decarboxylase 67 (GAD67), encoded by the Gad1 gene, is a consistent finding in postmortem brains of patients with several psychiatric disorders, including schizophrenia, bipolar disorder and...
8.
Fujihara K, Sato T, Miyasaka Y, Mashimo T, Yanagawa Y
FEBS Open Bio
. 2020 Dec;
11(2):340-353.
PMID: 33325157
The GABAergic system is thought to play an important role in the control of cognition and emotion, such as fear, and is related to the pathophysiology of psychiatric disorders. For...
9.
Fujihara K, Yamada K, Ichitani Y, Kakizaki T, Jiang W, Miyata S, et al.
Transl Psychiatry
. 2020 Dec;
10(1):426.
PMID: 33293518
GABAergic dysfunctions have been implicated in the pathogenesis of schizophrenia, especially the associated cognitive impairments. The GABA synthetic enzyme glutamate decarboxylase 67-kDa isoform (GAD67) encoded by the GAD1 gene is...
10.
Sunaga M, Takei Y, Kato Y, Tagawa M, Suto T, Hironaga N, et al.
Front Psychiatry
. 2020 Jul;
11:597.
PMID: 32670117
Background: Bipolar disorder (BD) is a serious psychiatric disorder that is associated with a high suicide rate, and for which no clinical biomarker has yet been identified. To address this...