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Kazutake Shimada

Explore the profile of Kazutake Shimada including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 45
Citations 325
Followers 0
Related Specialties
Chemistry
Biochemistry
Biomedical Engineering
Top 10 Co-Authors
Tatsuya Higashi
Tadashi Nishio
Kuniko Mitamura
Mikio Namiki
Yujin Shibayama
Eitetsu Koh
Akinori Yamauchi
Atsushi Mizokami
Toshimasa Toyooka
Naoki Takayama
Published In
J Chromatogr B Analyt Technol Biomed Life Sci
J Pharm Biomed Anal
Anal Sci
Steroids
Biomed Chromatogr
Affiliations
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Recent Articles
1.
Application of Cookson-type reagents for biomedical HPLC and LC/MS analyses: a brief overview
Higashi T, Shimada K
Biomed Chromatogr . 2016 Aug; 31(1). PMID: 27511712
High-performance liquid chromatography (HPLC), LC/mass spectrometry (MS) and LC/tandem mass spectrometry (MS/MS) have been widely used for biomedical analyses, in which chemical derivatization is one of the most important methods...
2.
A specific LC/ESI-MS/MS method for determination of 25-hydroxyvitamin D3 in neonatal dried blood spots containing a potential interfering metabolite, 3-epi-25-hydroxyvitamin D3
Higashi T, Suzuki M, Hanai J, Inagaki S, Min J, Shimada K, et al.
J Sep Sci . 2011 Feb; 34(7):725-32. PMID: 21328697
Vitamin D deficiency in an infant is associated with a wide range of adverse health outcomes in later life. A method for the quantification of 25-hydroxyvitamin D(3) [25(OH)D(3), the best-established...
3.
Salivary chenodeoxycholic acid and its glycine-conjugate: their determination method using LC-MS/MS and variation of their concentrations with increased saliva flow rate
Higashi T, Shibayama Y, Ichikawa T, Ito K, Toyooka T, Shimada K, et al.
Steroids . 2010 Feb; 75(4-5):338-45. PMID: 20117124
Measurement of steroid levels in saliva has been proposed as a new laboratory tool for characterizing steroid metabolism, but it is not known whether the salivary levels of bile acids...
4.
Advances in determination of vitamin D related compounds in biological samples using liquid chromatography-mass spectrometry: a review
Higashi T, Shimada K, Toyooka T
J Chromatogr B Analyt Technol Biomed Life Sci . 2009 Dec; 878(20):1654-61. PMID: 19962356
The measurements of the serum/plasma concentrations of vitamin D metabolites are widely used for the diagnostic assessment and follow-up of several diseases, such as chronic renal failure and osteoporosis. These...
5.
Analyses of biologically active steroids: antitumor active OSW-1 and cardiotonic marinobufotoxin, by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight tandem mass spectrometry
Kasai H, Tsubuki M, Shimada K, Nambara T, Honda T
Chem Pharm Bull (Tokyo) . 2009 Sep; 57(9):948-56. PMID: 19721255
Naturally occurring constituents of biological or pharmaceutical interest often exist in the form of glycosides or conjugates. Mass spectral investigations of these compounds require soft ionization techniques if information on...
6.
Studies on neurosteroids XXVI. Fluoxetine-evoked changes in rat brain and serum levels of neuroactive androgen, 5 alpha-androstane-3 alpha,17 beta-diol
Higashi T, Nagura Y, Shimada K, Toyooka T
Biol Pharm Bull . 2009 Sep; 32(9):1636-8. PMID: 19721248
It is well known that fluoxetine (Fluox), a selective serotonin reuptake inhibitor, increases the brain content of allopregnanolone (AP), a potent neuroactive steroid that positively modulates the action of gamma-aminobutyric...
7.
Simultaneous determination of salivary testosterone and dehydroepiandrosterone using LC-MS/MS: Method development and evaluation of applicability for diagnosis and medication for late-onset hypogonadism
Shibayama Y, Higashi T, Shimada K, Odani A, Mizokami A, Konaka H, et al.
J Chromatogr B Analyt Technol Biomed Life Sci . 2008 Nov; 877(25):2615-23. PMID: 19010090
Late-onset hypogonadism (LOH) is a male-specific disorder caused by the age-related decline in androgens, such as testosterone (T). A sensitive liquid chromatography-electrospray ionization-tandem mass spectrometric (LC-ESI-MS/MS) method for the simultaneous...
8.
Studies on neurosteroids XXV. Influence of a 5alpha-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism
Mukai Y, Higashi T, Nagura Y, Shimada K
Biol Pharm Bull . 2008 Sep; 31(9):1646-50. PMID: 18758053
In this study, we examined the influence of finasteride (FIN), a 5alpha-reductase inhibitor, on the brain levels and metabolism of neurosteroids [allopregnanolone (AP), 3alpha-dihydroprogesterone (3alpha-DHP), progesterone (PROG), 20alpha-dihydroprogesterone and 11-deoxycorticosterone...
9.
Studies on neurosteroids XX. Liquid chromatography-tandem mass spectrometric method for simultaneous determination of testosterone and 5alpha-dihydrotestosterone in rat brain and serum
Higashi T, Ninomiya Y, Shimada K
J Chromatogr Sci . 2008 Aug; 46(7):653-8. PMID: 18718144
Testosterone (T) and 5alpha-dihydrotestosterone (DHT) are now referred to not only as androgenic steroid hormones, but also as neuroactive steroids, because they elicit anesthetic and anxiolytic effects. Methods using liquid...
10.
Studies on neurosteroids XXIV. Determination of neuroactive androgens, androsterone and 5alpha-androstane-3alpha,17beta-diol, in rat brain and serum using liquid chromatography-tandem mass spectrometry
Higashi T, Yokoi H, Nagura Y, Nishio T, Shimada K
Biomed Chromatogr . 2008 Jul; 22(12):1434-41. PMID: 18655222
The development and validation of liquid chromatography-electrospray ionization-tandem mass spectrometric (LC-ESI-MS/MS) methods that enable the quantification of neuroactive androgens, androsterone (5alpha-androstan-3alpha-ol-17-one, 3alpha,5alpha-A) and 5alpha-androstane-3alpha,17beta-diol (3alpha,5alpha-Adiol), in the rat brain and...