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Kazuhiko Watabe

Explore the profile of Kazuhiko Watabe including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 68
Citations 630
Followers 0
Related Specialties
Neurology
Pathology
Chemistry
Top 10 Co-Authors
Kazunori Sango
Emiko Kawakami
Hiroko Yanagisawa
Shizuka Takaku
Yoko Kawazoe
Toshio Shimizu
Kiyomitsu Oyanagi
Tsuyoshi Sakamoto
Akihiro Kawata
Yuichi Hayashi
Published In
Neuropathology
J Neurosci Res
J Neurochem
J Hum Genet
PLoS One
Affiliations
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Recent Articles
1.
Human transthyretin gene expression is markedly increased in repair Schwann cells in an in vitro model of hereditary transthyretin amyloidosis
Murakami T, Ito Y, Sango K, Watabe K, Sunada Y
Neurochem Int . 2023 Feb; 164:105507. PMID: 36796540
Hereditary transthyretin (TTR) amyloidosis (ATTRv) is characterized by TTR amyloid deposition in the peripheral nervous system. It remains unknown why variant TTR preferentially deposits in the peripheral nerves and dorsal...
2.
The Protective Effect of Edaravone on TDP-43 Plus Oxidative Stress-Induced Neurotoxicity in Neuronal Cells: Analysis of Its Neuroprotective Mechanisms Using RNA Sequencing
Soejima-Kusunoki A, Okada K, Saito R, Watabe K
Pharmaceuticals (Basel) . 2022 Jul; 15(7). PMID: 35890141
Edaravone is a free-radical scavenger drug that was recently approved for the treatment of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease. A pathological hallmark of ALS is the accumulation of...
3.
Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation
Watabe K, Niida-Kawaguchi M, Tada M, Kato Y, Murata M, Tanji K, et al.
Neuropathology . 2022 Jun; 42(6):488-504. PMID: 35701899
The formation of misfolded protein aggregates is one of the pathological hallmarks of neurodegenerative diseases. We have previously demonstrated the cytoplasmic aggregate formation of adenovirally expressed transactivation response DNA-binding protein...
4.
Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis
Kazama M, Kato Y, Kakita A, Noguchi N, Urano Y, Masui K, et al.
Neuropathology . 2020 Dec; 40(6):587-598. PMID: 33305472
A vast body of evidence implicates increased oxidative stress and extracellular glutamate accumulation in the pathomechanism of sporadic amyotrophic lateral sclerosis (ALS). Cystine/glutamate antiporter (xCT) carries extracellular cystine uptake and...
5.
A low amyloidogenic E61K transthyretin mutation may cause familial amyloid polyneuropathy
Murakami T, Yokoyama T, Mizuguchi M, Tone S, Takaku S, Sango K, et al.
J Neurochem . 2020 Aug; 156(6):957-966. PMID: 32852783
Patients with transthyretin (TTR)-type familial amyloid polyneuropathy (FAP) typically exhibit sensory dominant polyneuropathy and autonomic neuropathy. However, the molecular pathogenesis of the neuropathy remains unclear. In this study, we characterize...
6.
Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation
Watabe K, Kato Y, Sakuma M, Murata M, Niida-Kawaguchi M, Takemura T, et al.
Neuropathology . 2020 Jul; 40(6):570-586. PMID: 32686212
Transactivation response DNA-binding protein of 43 kDa (TDP-43) is a major constituent of cytoplasmic aggregates in neuronal and glial cells in cases of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar...
7.
Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis
Niida-Kawaguchi M, Kakita A, Noguchi N, Kazama M, Masui K, Kato Y, et al.
Neuropathology . 2019 Dec; 40(2):152-166. PMID: 31883180
Previous studies on sporadic amyotrophic lateral sclerosis (SALS) demonstrated iron accumulation in the spinal cord and increased glutamate concentration in the cerebrospinal fluid. To clarify the relationship between the two...
8.
SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes
Moriwaki Y, Ohno Y, Ishii T, Takamura Y, Kita Y, Watabe K, et al.
PLoS One . 2018 Jun; 13(6):e0199829. PMID: 29953492
Small integral membrane protein of the lysosome/late endosome (SIMPLE) is a 161-amino acid cellular protein that contains a characteristic C-terminal domain known as the SIMPLE-like domain (SLD), which is well...
9.
A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism
Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, et al.
J Neurochem . 2017 Dec; 144(6):710-722. PMID: 29238976
The increased glucose flux into the polyol pathway via aldose reductase (AR) is recognized as a major contributing factor for the pathogenesis of diabetic neuropathy, whereas little is known about...
10.
L-leucine and SPNS1 coordinately ameliorate dysfunction of autophagy in mouse and human Niemann-Pick type C disease
Yanagisawa H, Ishii T, Endo K, Kawakami E, Nagao K, Miyashita T, et al.
Sci Rep . 2017 Nov; 7(1):15944. PMID: 29162837
Lysosomal storage disorders are characterized by progressive accumulation of undigested macromolecules within the cell due to lysosomal dysfunction. 573C10 is a Schwann cell line derived from a mouse model of...