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Kayo Ikuta

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Articles 12
Citations 81
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Recent Articles
1.
Joho D, Takahashi M, Suzuki T, Ikuta K, Matsumoto M, Kakeyama M
Brain Commun . 2023 Nov; 5(6):fcad311. PMID: 38025274
Cognitive flexibility, the ability of adapting to an ever-changing environment, declines with aging and impaired in early stages of dementia. Although recent studies have indicated there is a relationship between...
2.
Ikuta K, Joho D, Kakeyama M, Matsumoto M
Front Nutr . 2023 Jun; 10:1164809. PMID: 37346910
The relationship between intestinal microbiota and cognitive function has been investigated as one of the major topics within the intestinal microbiota-gut-brain axis. Although an increasing number of studies have demonstrated...
3.
Tamada H, Ikuta K, Makino Y, Joho D, Suzuki T, Kakeyama M, et al.
Front Neurosci . 2022 Jul; 16:882339. PMID: 35812208
Cognitive flexibility is the ability to rapidly adapt to a constantly changing environment. It is impaired by aging as well as in various neurological diseases, including dementia and mild cognitive...
4.
Hanazaki A, Ikuta K, Sasaki S, Sasaki S, Koike M, Tanifuji K, et al.
Physiol Rep . 2020 Feb; 8(3):e14324. PMID: 32026654
SLC34A3/NPT2c/NaPi-2c/Npt2c is a growth-related NaPi cotransporter that mediates the uptake of renal sodium-dependent phosphate (Pi). Mutation of human NPT2c causes hereditary hypophosphatemic rickets with hypercalciuria. Mice with Npt2c knockout, however,...
5.
Ikuta K, Segawa H, Hanazaki A, Fujii T, Kaneko I, Shiozaki Y, et al.
Pflugers Arch . 2018 Dec; 471(1):123-136. PMID: 30523405
Inorganic phosphate (Pi) secretion from the salivary glands and dietary Pi are key Pi sources. The regulatory mechanisms of Pi homeostasis in the salivary glands are unknown. We investigated how...
6.
Sasaki S, Segawa H, Hanazaki A, Kirino R, Fujii T, Ikuta K, et al.
Kidney Blood Press Res . 2018 Sep; 43(5):1409-1424. PMID: 30212831
Background/aims: Hyperphosphatemia is a serious complication of late-stage chronic kidney disease (CKD). Intestinal inorganic phosphate (Pi) handling plays an important role in Pi homeostasis in CKD. We investigated whether intestinal...
7.
Kaneko I, Segawa H, Ikuta K, Hanazaki A, Fujii T, Tatsumi S, et al.
Endocrinology . 2018 Jun; 159(7):2741-2758. PMID: 29878089
X-linked hypophosphatemia (XLH), the most common form of inheritable rickets, is caused by inactivation of phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) and leads to fibroblast...
8.
Miyagawa A, Tatsumi S, Takahama W, Fujii O, Nagamoto K, Kinoshita E, et al.
Kidney Int . 2018 Feb; 93(5):1073-1085. PMID: 29398136
Circulating inorganic phosphate exhibits a remarkable daily oscillation based on food intake. In humans and rodents, the daily oscillation in response to food intake may be coordinated to control the...
9.
Fujii O, Tatsumi S, Ogata M, Arakaki T, Sakaguchi H, Nomura K, et al.
Front Endocrinol (Lausanne) . 2018 Jan; 8:359. PMID: 29312149
In response to kidney damage, osteocytes increase the production of several hormones critically involved in mineral metabolism. Recent studies suggest that osteocyte function is altered very early in the course...
10.
Ikuta K, Segawa H, Sasaki S, Hanazaki A, Fujii T, Kushi A, et al.
Clin Exp Nephrol . 2017 Nov; 22(3):517-528. PMID: 29128884
Background: Hyperphosphatemia is common in chronic kidney disease and is associated with morbidity and mortality. The intestinal Na-dependent phosphate transporter Npt2b is thought to be an important molecular target for...