Kay Osborn
Overview
Explore the profile of Kay Osborn including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
358
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0
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Recent Articles
1.
Godfrey A, Osborn K, Sinclair A
Access Microbiol
. 2022 Jan;
3(11):000282.
PMID: 35018326
Epstein-Barr virus (EBV) is present in a state of latency in infected memory B-cells and EBV-associated lymphoid and epithelial cancers. Cell stimulation or differentiation of infected B-cells and epithelial cells...
2.
Zhou Y, Heesom K, Osborn K, Almohammed R, Sweet S, Sinclair A
J Virol
. 2019 Nov;
94(3).
PMID: 31694936
The human gammaherpesvirus Epstein-Barr virus (EBV) (human herpesvirus 4 [HHV4]) infects most adults and is an important contributor to the development of many types of lymphoid and epithelial cancers. Essential...
3.
Almohammed R, Osborn K, Ramasubramanyan S, Perez-Fernandez I, Godfrey A, Mancini E, et al.
J Gen Virol
. 2018 Mar;
99(6):805-817.
PMID: 29580369
The human gamma herpes virus Epstein-Barr virus (EBV) exploits multiple routes to evade the cellular immune response. During the EBV lytic replication cycle, viral proteins are expressed that provide excellent...
4.
Balan N, Osborn K, Sinclair A
J Gen Virol
. 2015 Dec;
97(3):725-732.
PMID: 26653871
Repression of the cellular CIITA gene is part of the immune evasion strategy of the γherpes virus Epstein-Barr virus (EBV) during its lytic replication cycle in B-cells. In part, this...
5.
Ramasubramanyan S, Osborn K, Al-Mohammad R, Naranjo Perez-Fernandez I, Zuo J, Balan N, et al.
Nucleic Acids Res
. 2015 Mar;
43(7):3563-77.
PMID: 25779048
Lytic replication of the human gamma herpes virus Epstein-Barr virus (EBV) is an essential prerequisite for the spread of the virus. Differential regulation of a limited number of cellular genes...
6.
Ramasubramanyan S, Kanhere A, Osborn K, Flower K, Jenner R, Sinclair A
J Virol
. 2012 Sep;
86(23):12494-502.
PMID: 23015699
The Epstein-Barr virus (EBV) genome sustains substantial epigenetic modification involving chromatin remodelling and DNA methylation during lytic replication. Zta (ZEBRA, BZLF1), a key regulator of the EBV lytic cycle, is...
7.
Dynamic chromatin environment of key lytic cycle regulatory regions of the Epstein-Barr virus genome
Ramasubramanyan S, Osborn K, Flower K, Sinclair A
J Virol
. 2011 Nov;
86(3):1809-19.
PMID: 22090141
The ability of Epstein-Barr virus (EBV) to establish latency allows it to evade the immune system and to persist for the lifetime of its host; one distinguishing characteristic is the...
8.
Cortes Ledesma F, El Khamisy S, Zuma M, Osborn K, Caldecott K
Nature
. 2009 Oct;
461(7264):674-8.
PMID: 19794497
Topoisomerases regulate DNA topology and are fundamental to many aspects of chromosome metabolism. Their activity involves the transient cleavage of DNA, which, if it occurs near sites of endogenous DNA...