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Kautilya Kumar Jena

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Articles 16
Citations 346
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Recent Articles
1.
Chauhan N, Kundu S, Bal R, Chattopadhyay D, Sahu R, Mehto S, et al.
Cell Rep . 2023 Oct; 42(11):113275. PMID: 37874678
Type I interferon (IFN-I) response is the first line of host defense against invading viruses. In the absence of definite mouse models, the role of IFN-I in SARS-CoV-2 infection remains...
2.
Mehto S, Jena K, Yadav R, Priyadarsini S, Samal P, Krishna S, et al.
EMBO J . 2022 Oct; 41(23):e111289. PMID: 36221902
The NOD1/2-RIPK2 is a key cytosolic signaling complex that activates NF-κB pro-inflammatory response against invading pathogens. However, uncontrolled NF-κB signaling can cause tissue damage leading to chronic diseases. The mechanisms...
3.
Saha S, Samal P, Madhulika S, Murmu K, Chakraborty S, Basu J, et al.
Blood Adv . 2022 Jan; 6(10):3106-3113. PMID: 35078226
No abstract available.
4.
Chauhan S, Jena K, Mehto S, Chauhan N, Sahu R, Dhar K, et al.
FEBS J . 2021 Nov; 289(14):4112-4131. PMID: 34826185
Extensive crosstalk exists between autophagy and innate immune signalling pathways. The stimuli that induce pattern recognition receptor (PRR)-mediated innate immune signalling pathways, also upregulate autophagy. The purpose of this increased...
5.
Nath P, Chauhan N, Jena K, Datey A, Dinesh Kumar N, Mehto S, et al.
EMBO Rep . 2021 Sep; 22(11):e52948. PMID: 34467632
The type I interferon (IFN) response is the major host arsenal against invading viruses. IRGM is a negative regulator of IFN responses under basal conditions. However, the role of human...
6.
Banerjee A, Pradhan L, Sahoo P, Jena K, Chauhan N, Chauhan S, et al.
Arch Microbiol . 2021 Mar; 203(6):2895-2910. PMID: 33763767
Increasing incidences of neurological disorders, such as Parkinson's disease (PD), multiple sclerosis (MS), Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) are being reported, but an insight into their pathology...
7.
Nath P, Jena K, Mehto S, Chauhan N, Sahu R, Dhar K, et al.
Autophagy . 2020 Aug; 17(2):578-580. PMID: 32813580
IRGM is a genetic risk factor for several autoimmune diseases. However, the mechanism of IRGM-mediated protection in autoimmunity remains undetermined. The abnormal activation of type I interferon (IFN) response is...
8.
Jena K, Mehto S, Nath P, Chauhan N, Sahu R, Dhar K, et al.
EMBO Rep . 2020 Jul; 21(9):e50051. PMID: 32715615
Activation of the type 1 interferon response is extensively connected to the pathogenesis of autoimmune diseases. Loss of function of Immunity Related GTPase M (IRGM) has also been associated to...
9.
Jena K, Mehto S, Kolapalli S, Nath P, Chauhan S, Chauhan S
Cell Stress . 2019 Jun; 2(12):365-367. PMID: 31225461
The cellular stresses, genetic mutations, and environmental factors can critically affect the protein quality control checkpoints resulting in protein misfolding. Molecular chaperones play a crucial role in maintaining the healthy...
10.
Mehto S, Chauhan S, Jena K, Chauhan N, Nath P, Sahu R, et al.
Autophagy . 2019 Jun; 15(9):1645-1647. PMID: 31177914
IRGM is an established genetic risk factor for Crohn disease (CD) and several other inflammatory disorders. However, the mechanisms employed by IRGM to restrain the inflammation are not known. In...