Kathryn Gudsnuk
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Explore the profile of Kathryn Gudsnuk including associated specialties, affiliations and a list of published articles.
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15
Citations
1123
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Recent Articles
1.
Hunker A, Wirthlin M, Gill G, Johansen N, Hooper M, Omstead V, et al.
bioRxiv
. 2024 Oct;
PMID: 39386678
We present an enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits. Best-in-class vectors were curated for accessing major striatal neuron populations including medium spiny neurons (MSNs),...
2.
Kussick E, Johansen N, Taskin N, Wynalda B, Martinez R, Groce E, et al.
bioRxiv
. 2024 Aug;
PMID: 39131318
Experimental access to cell types within the mammalian spinal cord is severely limited by the availability of genetic tools. To enable access to lower motor neurons (LMNs) and LMN subtypes,...
3.
Mashoodh R, Habrylo I, Gudsnuk K, Champagne F
Horm Behav
. 2023 Apr;
152:105357.
PMID: 37062113
Paternal stress exposure is known to impact the development of stress-related behaviors in offspring. Previous work has highlighted the importance of sperm mediated factors, such as RNAs, in transmitting the...
4.
Course M, Gudsnuk K, Keene C, Bird T, Jayadev S, Valdmanis P
Brain
. 2022 Aug;
146(2):507-518.
PMID: 35949106
Alzheimer's disease is the most common neurodegenerative disease, characterized by dementia and premature death. Early-onset familial Alzheimer's disease is caused in part by pathogenic variants in presenilin 1 (PSEN1) and...
5.
Course M, Sulovari A, Gudsnuk K, Eichler E, Valdmanis P
Genome Res
. 2021 Jul;
31(8):1313-1324.
PMID: 34244228
There are more than 55,000 variable number tandem repeats (VNTRs) in the human genome, notable for both their striking polymorphism and mutability. Despite their role in human evolution and genomic...
6.
Course M, Gudsnuk K, Smukowski S, Winston K, Desai N, Ross J, et al.
Am J Hum Genet
. 2020 Aug;
107(3):445-460.
PMID: 32750315
Tandem repeats are proposed to contribute to human-specific traits, and more than 40 tandem repeat expansions are known to cause neurological disease. Here, we characterize a human-specific 69 bp variable...
7.
Course M, Gudsnuk K, Desai N, Chamberlain J, Valdmanis P
Mol Ther Nucleic Acids
. 2020 Jan;
19:572-580.
PMID: 31927330
Gene knockdown using short hairpin RNAs (shRNAs) is a promising strategy for targeting dominant mutations; however, delivering too much shRNA can disrupt the processing of endogenous microRNAs (miRNAs) and lead...
8.
Course M, Gudsnuk K, Valdmanis P
J Vis Exp
. 2019 Sep;
(150).
PMID: 31498311
Half of all human transcripts are thought to be regulated by microRNAs. Therefore, quantifying microRNA expression can reveal underlying mechanisms in disease states and provide therapeutic targets and biomarkers. Here,...
9.
Miller R, Yan Z, Maher C, Zhang H, Gudsnuk K, McDonald J, et al.
Neuroepigenetics
. 2016 Apr;
5:11-18.
PMID: 27088078
Prenatal exposure to polycyclic aromatic hydrocarbons (PAH) has been associated with sustained effects on the brain and behavior in offspring. However, the mechanisms have yet to be determined. We hypothesized...
10.
Brunelli S, Curley J, Gudsnuk K, Champagne F, Myers M, Hofer M, et al.
Horm Behav
. 2015 Aug;
75:78-83.
PMID: 26306860
Individual differences in maternal behavior in rodents are associated with altered physiology and behavior in offspring across their lifespan and across generations. Offspring of rat dams that engage in high...