Kathryn Futrega
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Explore the profile of Kathryn Futrega including associated specialties, affiliations and a list of published articles.
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31
Citations
424
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Recent Articles
1.
Gadomski S, Mui B, Gorodetsky R, Paravastu S, Featherall J, Li L, et al.
iScience
. 2024 Aug;
27(8):110537.
PMID: 39193188
Stem cell therapies for degenerative cartilage disease are limited by an incomplete understanding of hyaline cartilage formation and maintenance. Human bone marrow stromal cells/skeletal stem cells (hBMSCs/SSCs) produce stable hyaline...
2.
Franco R, McKenna E, Shajib M, Guillesser B, Robey P, Crawford R, et al.
Cells
. 2024 Jan;
13(1).
PMID: 38201241
Chondrogenic induction of bone-marrow-derived stromal cells (BMSCs) is typically accomplished with medium supplemented with growth factors (GF) from the transforming growth factor-beta (TGF-β)/bone morphogenetic factor (BMP) superfamily. In a previous...
3.
Shajib M, Futrega K, Davies A, Franco R, McKenna E, Guillesser B, et al.
J R Soc Interface
. 2023 Oct;
20(207):20230468.
PMID: 37817581
If it were possible to purchase tumour-spheroids as a standardised product, ready for direct use in assays, this may contribute to greater research reproducibility, potentially reducing costs and accelerating outcomes....
4.
Shajib M, Futrega K, Franco R, McKenna E, Guillesser B, Klein T, et al.
J Tissue Eng
. 2023 Aug;
14:20417314231176901.
PMID: 37529249
The financial viability of a cell and tissue-engineered therapy may depend on the compatibility of the therapy with mass production and cryopreservation. Herein, we developed a method for the mass...
5.
Franco R, McKenna E, Robey P, Crawford R, Doran M, Futrega K
J Tissue Eng
. 2023 Jun;
14:20417314231177136.
PMID: 37362901
For bone marrow stromal cells (BMSC) to be useful in cartilage repair their propensity for hypertrophic differentiation must be overcome. A single day of TGF-β1 stimulation activates intrinsic signaling cascades...
6.
McKenna E, Futrega K, Klein T, Altalhi T, Popat A, Kumeria T, et al.
Biofabrication
. 2023 Jan;
15(2).
PMID: 36595260
Spray nebulization is an elegant, but relatively unstudied, technique for scaffold production. Herein we fabricated mesh scaffolds of polycaprolactone (PCL) nanofibers via spray nebulization of 8% PCL in dichloromethane (DCM)...
7.
Franco R, McKenna E, Robey P, Shajib M, Crawford R, Doran M, et al.
Stem Cell Reports
. 2022 Feb;
17(3):616-632.
PMID: 35180395
Bone morphogenetic protein (BMP) cascades are upregulated during bone marrow-derived stromal cell (BMSC) chondrogenesis, contributing to hypertrophy and preventing effective BMSC-mediated cartilage repair. Previous work demonstrated that a proprietary BMP...
8.
Shajib M, Futrega K, Klein T, Crawford R, Doran M
J Tissue Eng
. 2022 Jan;
13:20417314221074207.
PMID: 35096364
When repairing cartilage defects a major challenge is achieving high-quality integration between the repair tissue and adjacent native cartilage. Matrix-rich cartilage is not easily remodeled, motivating several studies to trial...
9.
de Castro L, Sworder B, Mui B, Futrega K, Berendsen A, Phillips M, et al.
Bone Res
. 2021 Dec;
9(1):49.
PMID: 34857734
In a previous transcriptomic study of human bone marrow stromal cells (BMSCs, also known as bone marrow-derived "mesenchymal stem cells"), SFRP2 was highly over-represented in a subset of multipotent BMSCs...
10.
Nowlan B, Futrega K, Williams E, Doran M
Stem Cell Res Ther
. 2021 Apr;
12(1):231.
PMID: 33845908
Background: Direct bone marrow injection of cells into murine marrow cavities is used in a range of cell characterization assays and to develop disease models. While human bone marrow-derived stromal...