Kathleen E Brummel-Ziedins
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Explore the profile of Kathleen E Brummel-Ziedins including associated specialties, affiliations and a list of published articles.
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43
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743
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Recent Articles
11.
Gissel M, Tomkiewicz-Pajak L, Podolec P, Hoffman P, Trojnarska O, Lipczynska M, et al.
Blood Coagul Fibrinolysis
. 2018 Feb;
29(2):236-240.
PMID: 29406387
: Single-ventricle defects are associated with increased risk of thromboembolic events. To analyze the prothrombotic potential in a long-term follow-up on Fontan patients via plasma contribution to thrombin and factor...
12.
Cruz M, Luker J, Carney B, Brummel-Ziedins K, Bravo M, Orfeo T, et al.
Thromb J
. 2018 Jan;
15:31.
PMID: 29299031
Background: A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague Dawley rats using the mini cup...
13.
Haynes L, Orfeo T, Mann K, Everse S, Brummel-Ziedins K
Biophys J
. 2017 Apr;
112(8):1634-1644.
PMID: 28445754
In closed system models of fibrin formation, exosite-mediated thrombin binding to fibrin contributes to clot stability and is resistant to inhibition by antithrombin/heparin while still susceptible to small, active-site inhibitors....
14.
Tejiram S, Brummel-Ziedins K, Orfeo T, Mete M, Desale S, Hamilton B, et al.
J Surg Res
. 2016 May;
202(2):341-51.
PMID: 27229109
Background: Studies associating coagulopathic changes with burn injury have relied on limited tests such as partial thromboplastin time (PTT) and international normalized ratio (INR). Understanding the clotting dynamics and associated...
15.
Bouchard B, Chapin J, Brummel-Ziedins K, Durda P, Key N, Tracy P
Blood
. 2015 Apr;
125(23):3647-50.
PMID: 25896652
Whole genome sequencing of an individual completely devoid of plasma- and platelet-derived factor V (FV) identified 167 variants in his F5 gene including previously identified and damaging missense mutations at...
16.
Brummel-Ziedins K, Wolberg A
Curr Opin Hematol
. 2014 Jul;
21(5):395-403.
PMID: 25054908
Purpose Of Review: There exists an imbalance between our understanding of the physiology of the blood coagulation process and the translation of this understanding into useful assays for clinical application....
17.
Brummel-Ziedins K
Thromb Res
. 2014 Apr;
133 Suppl 1:S9-S11.
PMID: 24759148
Global assays and computational models have advanced research into the realm of individualized profiling of hemostatic states. This brief review will describe one computational approach which utilizes an integrated method...
18.
Sharma D, Brummel-Ziedins K, Bouchard B, Holmes C
J Cell Physiol
. 2013 Dec;
229(8):1005-15.
PMID: 24374897
While platelets are well known to play a central role in hemostasis and thrombosis, there is emerging experimental evidence to suggest that they also mediate tumor cell growth, dissemination, and...
19.
Whelihan M, Kiankhooy A, Brummel-Ziedins K
J Crit Care
. 2013 Dec;
29(1):24-30.
PMID: 24331944
Background: Despite trauma-induced hypothermic coagulopathy being familiar in the clinical setting, empirical experimentation concerning this phenomenon is lacking. In this study, we investigated the effects of hypothermia on thrombin generation,...
20.
Brummel-Ziedins K, Everse S, Mann K, Orfeo T
J Thromb Thrombolysis
. 2013 Nov;
37(1):32-44.
PMID: 24214371
Thrombin has multiple functions in blood coagulation and its regulation is central to maintaining the balance between hemorrhage and thrombosis. Empirical and computational methods that capture thrombin generation can provide...