Kathirvel Kandasamy
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Explore the profile of Kathirvel Kandasamy including associated specialties, affiliations and a list of published articles.
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11
Citations
134
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Recent Articles
1.
Kadam A, Kandasamy K, Buss T, Cederstrom B, Yang C, Narayanapillai S, et al.
PLoS One
. 2022 Nov;
17(11):e0276462.
PMID: 36413536
The long-sought-after "magic bullet" in systemic therapy remains unrealized for disease targets existing inside most tissues, theoretically because vascular endothelium impedes passive tissue entry and full target engagement. We engineered...
2.
Kandasamy K, Thirumalmuthu K, Prajna N, Lalitha P, Mohankumar V, Devarajan B
Genomics
. 2020 Sep;
112(6):4769-4776.
PMID: 32882326
The several virulence and drug-resistance mechanisms of Pseudomonas aeruginosa responsible for poor clinical outcomes in keratitis patients remain largely unknown. Here, we investigated the distribution of virulence factors and drug...
3.
Brown K, Filuta A, Ludwig M, Seuwen K, Jaros J, Vidal S, et al.
JCI Insight
. 2017 Jun;
2(11).
PMID: 28570277
Pulmonary function is dependent upon the precise regulation of alveolar surfactant. Alterations in pulmonary surfactant concentrations or function impair ventilation and cause tissue injury. Identification of the molecular pathways that...
4.
Escue R, Kandasamy K, Parthasarathi K
Am J Pathol
. 2017 Feb;
187(4):921-935.
PMID: 28188112
Activation of plasma membrane receptors initiates compartmentalized second messenger signaling. Whether this compartmentalization facilitates the preferential intercellular diffusion of specific second messengers is unclear. Toward this, the receptor-mediated agonist, thrombin,...
5.
Kandasamy K, Escue R, Manna J, Adebiyi A, Parthasarathi K
Am J Physiol Lung Cell Mol Physiol
. 2015 Jul;
309(6):L584-92.
PMID: 26163513
Endothelial barrier restoration reverses microvessel hyperpermeability and facilitates recovery from lung injury. Because inhibiting connexin 43 (Cx43)-dependent interendothelial communication blunts hyperpermeability in single microvessels, we determined whether endothelial Cx43 levels...
6.
Leo M, Kandasamy K, Subramani J, Tandan S, Kumar D
Cardiovasc Pathol
. 2014 Oct;
24(1):49-55.
PMID: 25294342
Chronic administration of Nω-nitro-L-arginine methyl ester (L-NAME) in rats is a chemical method to study the induction and progression of nitric oxide (NO) deficiency-induced endothelial dysfunction. Male Wistar rats received...
7.
Kandasamy K, Parthasarathi K
J Vis Exp
. 2014 Jul;
(88):e51552.
PMID: 25045895
The isolated blood-perfused lung preparation is widely used to visualize and define signaling in single microvessels. By coupling this preparation with real time imaging, it becomes feasible to determine permeability...
8.
Kandasamy K, Bezavada L, Escue R, Parthasarathi K
PLoS One
. 2013 May;
8(5):e63465.
PMID: 23675486
The pulmonary microvasculature plays a critical role in endotoxin-induced acute lung injury. However, the relevant signaling remain unclear. Specifically the role of endothelial Ca(2+) in the induction of endotoxin-mediated responses...
9.
Kandasamy K, Sahu G, Parthasarathi K
Microvasc Res
. 2012 Feb;
83(3):323-31.
PMID: 22342350
Endotoxemia, a major feature of sepsis, is a common cause of acute lung injury and initiates rapid accumulation of leukocytes in the lung vasculature. Endothelial mechanisms that underlie this accumulation...
10.
Makena P, Gorantla V, Ghosh M, Bezawada L, Kandasamy K, Balazs L, et al.
Am J Respir Cell Mol Biol
. 2011 Nov;
46(4):461-9.
PMID: 22052879
Both hyperoxia and mechanical ventilation can independently cause lung injury. In combination, these insults produce accelerated and severe lung injury. We recently reported that pre-exposure to hyperoxia for 12 hours,...