Katherine R Duncan
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Explore the profile of Katherine R Duncan including associated specialties, affiliations and a list of published articles.
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25
Citations
2438
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Recent Articles
1.
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, et al.
Nucleic Acids Res
. 2024 Dec;
53(D1):D678-D690.
PMID: 39657789
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is...
2.
Poynton E, van Santen J, Pin M, Contreras M, McMann E, Parra J, et al.
Nucleic Acids Res
. 2024 Nov;
53(D1):D691-D699.
PMID: 39588755
The Natural Products Atlas is a database of microbially derived natural products that contains structures, producing organism taxonomy, biosynthetic and chemical ontology classifications, grouping by compound classes and cross-links to...
3.
Whatmough B, Holmes N, Wilkinson B, Hutchings M, Parra J, Duncan K
Microbiology (Reading)
. 2024 Sep;
170(9).
PMID: 39297772
species comprise a genus of filamentous, sporulating bacteria belonging to the phylum Actinomycetota, formerly Actinobacteria. They are found in marine and freshwater sediments and soils and associated with marine animals,...
4.
Parra J, Jarmusch S, Duncan K
Environ Microbiol
. 2024 Jun;
26(6):e16635.
PMID: 38899724
Actinomycetes are a phylogenetically diverse bacterial group which are widely distributed across terrestrial and aquatic ecosystems. Within this order, the genus Pseudonocardia and their specialised metabolites have been the focus...
5.
Parra J, Beaton A, Seipke R, Wilkinson B, Hutchings M, Duncan K
Curr Opin Microbiol
. 2023 Oct;
76:102385.
PMID: 37804816
Throughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for their ability to produce bioactive metabolites. Yet, this success has been hampered by rediscovery. As we enter a...
6.
Mullowney M, Duncan K, Elsayed S, Garg N, van der Hooft J, Martin N, et al.
Nat Rev Drug Discov
. 2023 Sep;
22(11):895-916.
PMID: 37697042
Developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential for drug discovery. In parallel, artificial intelligence approaches such as...
7.
MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters
Terlouw B, Blin K, Navarro-Munoz J, Avalon N, Chevrette M, Egbert S, et al.
Nucleic Acids Res
. 2022 Nov;
51(D1):D603-D610.
PMID: 36399496
With an ever-increasing amount of (meta)genomic data being deposited in sequence databases, (meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs,...
8.
Feeney M, Newitt J, Addington E, Algora-Gallardo L, Allan C, Balis L, et al.
Microb Genom
. 2022 Jul;
8(7).
PMID: 35775972
Actinobacteria is an ancient phylum of Gram-positive bacteria with a characteristic high GC content to their DNA. The ActinoBase Wiki is focused on the filamentous actinobacteria, such as species, and...
9.
Hutchings M, Duncan K
Cell Host Microbe
. 2022 Mar;
30(3):273-274.
PMID: 35271795
Colistin is an antibiotic of last resort for treating Gram-negative bacterial infections, but resistance is spreading rapidly. In a recent issue of Nature, Wang et al. use genome mining to...
10.
van Santen J, Poynton E, Iskakova D, McMann E, Alsup T, Clark T, et al.
Nucleic Acids Res
. 2021 Oct;
50(D1):D1317-D1323.
PMID: 34718710
Within the natural products field there is an increasing emphasis on the study of compounds from microbial sources. This has been fuelled by interest in the central role that microorganisms...