Katarina Farnegardh
Overview
Explore the profile of Katarina Farnegardh including associated specialties, affiliations and a list of published articles.
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10
Citations
222
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Recent Articles
1.
Ladds M, van Leeuwen I, Drummond C, Chu S, Healy A, Popova G, et al.
Nat Commun
. 2023 Aug;
14(1):5019.
PMID: 37596290
No abstract available.
2.
Westermark U, Diao Y, Fasth K, Farnegardh M, Farnegardh K, Hammer K, et al.
Biochem Biophys Res Commun
. 2023 Apr;
656:122-130.
PMID: 37032581
Despite decades of development of treatments and the successful application of targeted therapies for multiple myeloma, clinical challenges remain for patients with relapsed/refractory disease. A drug designed for efficient delivery...
3.
Bonagas N, Gustafsson N, Henriksson M, Marttila P, Gustafsson R, Wiita E, et al.
Nat Cancer
. 2022 Mar;
3(2):156-172.
PMID: 35228749
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In...
4.
Gustafsson N, Farnegardh K, Bonagas N, Ninou A, Groth P, Wiita E, et al.
Nat Commun
. 2018 Sep;
9(1):3872.
PMID: 30250201
The glycolytic PFKFB3 enzyme is widely overexpressed in cancer cells and an emerging anti-cancer target. Here, we identify PFKFB3 as a critical factor in homologous recombination (HR) repair of DNA...
5.
Ladds M, van Leeuwen I, Drummond C, Chu S, Healy A, Popova G, et al.
Nat Commun
. 2018 May;
9(1):2071.
PMID: 29789663
The original PDF version of this Article listed the authors as "Marcus J.G.W. Ladds," where it should have read "Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine...
6.
Ladds M, van Leeuwen I, Drummond C, Chu S, Healy A, Popova G, et al.
Nat Commun
. 2018 Mar;
9(1):1107.
PMID: 29549331
The development of non-genotoxic therapies that activate wild-type p53 in tumors is of great interest since the discovery of p53 as a tumor suppressor. Here we report the identification of...
7.
Gustafsson R, Jemth A, Gustafsson N, Farnegardh K, Loseva O, Wiita E, et al.
Cancer Res
. 2016 Dec;
77(4):937-948.
PMID: 27899380
To sustain their proliferation, cancer cells become dependent on one-carbon metabolism to support purine and thymidylate synthesis. Indeed, one of the most highly upregulated enzymes during neoplastic transformation is MTHFD2,...
8.
Hammarstrom L, Harmel R, Granath M, Ringom R, Gravenfors Y, Farnegardh K, et al.
J Med Chem
. 2016 Sep;
59(18):8577-92.
PMID: 27607569
Glioblastoma remains an incurable brain cancer. Drugs developed in the past 20 years have not improved the prognosis for patients, necessitating the development of new treatments. We have previously reported...
9.
Zovko A, Novak M, Haag P, Kovalerchick D, Holmlund T, Farnegardh K, et al.
Oncotarget
. 2016 Jul;
7(31):50258-50276.
PMID: 27384680
In this work two acetylene alcohols, compound 1 and compound 2, which were isolated and identified from the sponge Cribrochalina vasculum, and which showed anti-tumor effects were further studied with...
10.
Zovko A, Viktorsson K, Haag P, Kovalerchick D, Farnegardh K, Alimonti A, et al.
Mol Cancer Ther
. 2014 Oct;
13(12):2941-54.
PMID: 25319389
Marine-derived compounds have been explored and considered as possible antitumor agents. In this study, we analyzed extracts of the sponge Cribrochalina vasculum for their ability to inhibit tumor cell proliferation....