Karthigayan Gunalan
Overview
Explore the profile of Karthigayan Gunalan including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
642
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Recent Articles
1.
Lee S, Crosnier C, Valenzuela-Leon P, Dizon B, Atkinson J, Mu J, et al.
Proc Natl Acad Sci U S A
. 2024 Jan;
121(5):e2316304121.
PMID: 38261617
The discovery that Africans were resistant to infection by () led to the conclusion that invasion relied on the Duffy Binding Protein (PvDBP) interacting with the Duffy Antigen Receptor for...
2.
Duffy P, Gunalan K, Miller L
Cell Host Microbe
. 2023 Dec;
31(12):1959-1960.
PMID: 38096790
Duffy blood group antigen (Duffy antigen/receptor for chemokines, atypical chemokine receptor-1, Duffy antigen), an essential Plasmodium vivax invasion receptor, is absent in most Africans. In this issue, two papers show...
3.
Lee S, Low L, Andersen J, Yeoh L, Valenzuela Leon P, Drew D, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
120(1):e2215003120.
PMID: 36577076
We used a transgenic parasite in which parasites were genetically modified to express apical membrane antigen 1 (PvAMA1) protein in place of PfAMA1 to study PvAMA1-mediated invasion. In , AMA1...
4.
Lo E, Russo G, Pestana K, Kepple D, Abagero B, Dongho G, et al.
Int J Infect Dis
. 2021 May;
108:63-71.
PMID: 33991680
Objectives: Plasmodium vivax malaria was thought to be rare in Africans who lack the Duffy blood group antigen expression. However, recent studies indicate that P. vivax can infect Duffy-negative individuals...
5.
Dongho G, Gunalan K, LEpiscopia M, Paganotti G, Menegon M, Efeutmecheh Sangong R, et al.
Am J Trop Med Hyg
. 2021 Feb;
104(3):987-992.
PMID: 33534776
The Duffy blood group is a critical receptor for Plasmodium vivax (P. vivax) invasion of red blood cells, and consequently, P. vivax infections were considered rare in sub-Saharan Africa where...
6.
Ford A, Kepple D, Abagero B, Connors J, Pearson R, Auburn S, et al.
PLoS Negl Trop Dis
. 2020 Oct;
14(10):e0008234.
PMID: 33044985
Plasmodium vivax malaria is much less common in Africa than the rest of the world because the parasite relies primarily on the Duffy antigen/chemokine receptor (DARC) to invade human erythrocytes,...
7.
Verma N, Puri A, Essuman E, Skelton R, Anantharaman V, Zheng H, et al.
Sci Rep
. 2020 Jun;
10(1):9598.
PMID: 32533024
Babesia microti is an intraerythrocytic parasite and the primary causative agent of human babesiosis. It is transmitted by Ixodes ticks, transfusion of blood and blood products, organ donation, and perinatally....
8.
Gunalan K, Gao X, Yap S, Lai S, Ravasio A, Ganesan S, et al.
Cell Microbiol
. 2020 May;
22(9):e13232.
PMID: 32452132
Plasmodium falciparum responsible for the most virulent form of malaria invades human erythrocytes through multiple ligand-receptor interactions. The P. falciparum reticulocyte binding protein homologues (PfRHs) are expressed at the apical...
9.
Gunalan K, Rowley E, Miller L
Trends Parasitol
. 2020 May;
36(6):512-519.
PMID: 32360314
Trager and Jensen established a method for culturing Plasmodium falciparum, a breakthrough for malaria research worldwide. Since then, multiple attempts to establish Plasmodium vivax in continuous culture have failed. Unlike...
10.
Lo E, Hostetler J, Yewhalaw D, Pearson R, Hamid M, Gunalan K, et al.
PLoS Negl Trop Dis
. 2019 Sep;
13(9):e0007222.
PMID: 31509523
Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P....