Karthickeyan Chella Krishnan
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Explore the profile of Karthickeyan Chella Krishnan including associated specialties, affiliations and a list of published articles.
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Citations
562
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Recent Articles
1.
Talari N, Mattam U, Rahman A, Hemmelgarn B, Wyder M, Sylvestre P, et al.
Commun Biol
. 2025 Feb;
8(1):258.
PMID: 39966593
The role of peridroplet mitochondria (PDM) in diseased liver, such as during the progression of metabolic dysfunction-associated steatohepatitis (MASH), remains unknown. We isolated hepatic cytoplasmic mitochondria (CM) and PDM from...
2.
He X, Good A, Kalou W, Ahmad W, Dutta S, Chen S, et al.
Cells
. 2025 Jan;
13(24).
PMID: 39768189
Cardiovascular diseases resulting from myocardial infarction (MI) remain a leading cause of death worldwide, imposing a substantial burden on global health systems. Current MI treatments, primarily pharmacological and surgical, do...
3.
Mattam U, Talari N, Sathyanarayana A, Mia S, Frazier J, Slone S, et al.
bioRxiv
. 2024 Nov;
PMID: 39605365
Mitochondrial maladaptation is a hallmark of heart failure, contributing to impaired energy production and contractile dysfunction. Understanding the bioenergetics of cardiomyocytes under healthy and pathological conditions is critical for characterizing...
4.
Talari N, Mattam U, Kaminska D, Sotomayor-Rodriguez I, Rahman A, Peterfy M, et al.
iScience
. 2024 May;
27(5):109709.
PMID: 38689636
Recent studies demonstrate that liver secretory proteins, also known as hepatokines, regulate normal development, obesity, and simple steatosis to non-alcoholic steatohepatitis (NASH) progression. Using a panel of ∼100 diverse inbred...
5.
Chella Krishnan K
Elife
. 2023 Oct;
12.
PMID: 37855820
Gene expression profiling of a diverse mouse population helps to decipher how a fat-rich diet contributes to inflammatory bowel disease.
6.
Patel S, Sparman N, Arneson D, Alvarsson A, Santos L, Duesman S, et al.
Nature
. 2023 Jul;
620(7972):192-199.
PMID: 37495690
Sympathetic activation during cold exposure increases adipocyte thermogenesis via the expression of mitochondrial protein uncoupling protein 1 (UCP1). The propensity of adipocytes to express UCP1 is under a critical influence...
7.
Chella Krishnan K, El Hachem E, Keller M, Patel S, Carroll L, Vegas A, et al.
Elife
. 2023 Jun;
12.
PMID: 37276142
Mitochondria play an important role in both normal heart function and disease etiology. We report analysis of common genetic variations contributing to mitochondrial and heart functions using an integrative proteomics...
8.
Cao Y, Vergnes L, Wang Y, Pan C, Chella Krishnan K, Moore T, et al.
Nat Commun
. 2022 Jul;
13(1):3850.
PMID: 35787630
Heart failure with preserved ejection fraction (HFpEF) exhibits a sex bias, being more common in women than men, and we hypothesize that mitochondrial sex differences might underlie this bias. As...
9.
Chella Krishnan K, Vergnes L, Acin-Perez R, Stiles L, Shum M, Ma L, et al.
Nat Metab
. 2021 Oct;
3(11):1552-1568.
PMID: 34697471
We have previously suggested a central role for mitochondria in the observed sex differences in metabolic traits. However, the mechanisms by which sex differences affect adipose mitochondrial function and metabolic...
10.
Acin-Perez R, Petcherski A, Veliova M, Benador I, Assali E, Colleluori G, et al.
Redox Biol
. 2021 Aug;
46:102087.
PMID: 34411987
Beige adipocyte mitochondria contribute to thermogenesis by uncoupling and by ATP-consuming futile cycles. Since uncoupling may inhibit ATP synthesis, it is expected that expenditure through ATP synthesis is segregated to...