Karl Peter Giese
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Explore the profile of Karl Peter Giese including associated specialties, affiliations and a list of published articles.
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29
Citations
1055
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Recent Articles
1.
Bayer K, Giese K
Nat Neurosci
. 2024 Nov;
28(1):24-34.
PMID: 39558039
The Ca/calmodulin (CaM)-dependent protein kinase II (CaMKII) plays a fundamental role in learning and possibly also in memory. However, current mechanistic models require fundamental revision. CaMKII autophosphorylation at Thr286 (pThr286)...
2.
Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease
Rupawala H, Shah K, Davies C, Rose J, Colom-Cadena M, Peng X, et al.
Brain Commun
. 2022 Aug;
4(4):fcac192.
PMID: 35928052
In Alzheimer's disease, synapse loss causes memory and cognitive impairment. However, the mechanisms underlying synaptic degeneration in Alzheimer's disease are not well understood. In the hippocampus, alterations in the level...
3.
Rusakov D, Giese K, Sandi C, Dommett E, Overton P
Neuropharmacology
. 2022 Jan;
207:108962.
PMID: 35051447
No abstract available.
4.
Shetty M, Ris L, Schindler R, Mizuno K, Fedele L, Giese K, et al.
Cereb Cortex
. 2021 Dec;
32(16):3457-3471.
PMID: 34937090
Extensive research has uncovered diverse forms of synaptic plasticity and an array of molecular signaling mechanisms that act as positive or negative regulators. Specifically, cyclic 3',5'-cyclic adenosine monophosphate (cAMP)-dependent signaling...
5.
Giese K
Neuropharmacology
. 2021 May;
193:108616.
PMID: 34051268
Potentiation of glutamatergic synaptic transmission is thought to underlie memory. The induction of this synaptic potentiation relies on activation of NMDA receptors which allows for calcium influx into the post-synapse....
6.
Bear M, Cooke S, Giese K, Kaang B, Kennedy M, Kim J, et al.
Mol Brain
. 2018 Dec;
11(1):76.
PMID: 30593282
Shortly before he died in October 2017, John Lisman submitted an invited review to Molecular Brain on 'Criteria for identifying the molecular basis of the engram (CaMKII, PKMζ)'. John had...
7.
Vigil F, Giese K
J Neurochem
. 2018 Apr;
147(1):12-23.
PMID: 29704430
In this review, we discuss the poorly explored role of calcium/calmodulin-dependent protein kinase II (CaMKII) in memory maintenance, and its influence on memory destabilization. After a brief review on CaMKII...
8.
Vigil F, Mizuno K, Lucchesi W, Valls-Comamala V, Giese K
Sci Rep
. 2017 Jun;
7(1):4040.
PMID: 28642476
CaMK2N1 and CaMK2N2 are endogenous inhibitors of calcium/calmodulin-dependent protein kinase II (CaMKII), a key synaptic signaling molecule for learning and memory. Here, we investigated the learning and memory function of...
9.
Tiwari S, Mizuno K, Ghosh A, Aziz W, Troakes C, Daoud J, et al.
Brain
. 2016 Aug;
139(Pt 10):2751-2765.
PMID: 27524794
Characteristic features of Alzheimer's disease are memory loss, plaques resulting from abnormal processing of amyloid precursor protein (APP), and presence of neurofibrillary tangles and dystrophic neurites containing hyperphosphorylated tau. Currently,...
10.
Ghosh A, Giese K
Mol Brain
. 2015 Nov;
8(1):78.
PMID: 26603284
CaMKII is a remarkably complex protein kinase, known to have a fundamental role in synaptic plasticity and memory formation. Further, CaMKII has also been suggested to be a tau kinase....